The treatment of atrial fibrillation beyond pulmonary vein isolation has remained an unsolved challenge. Targeting regions identified by different substrate mapping approaches for ablation resulted in ambiguous outcomes. With the effective refractory period being a fundamental prerequisite for the maintenance of fibrillatory conduction, this study aims at estimating the effective refractory period with clinically available measurements.

中文翻译：

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人心房颤动期间的周期长度统计数据揭示了底层基质的难治性：概念研究的计算机模拟和临床试验相结合

除了肺静脉隔离之外，房颤的治疗仍然是一个未解决的挑战。通过用于消融的不同底物映射方法确定的靶向区域导致了模棱两可的结果。由于有效不应期是维持纤颤传导的基本先决条件，本研究旨在通过临床可用的测量来估计有效不应期。