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Developmental Insights into Lung Cancer
Annual Review of Cancer Biology ( IF 4.7 ) Pub Date : 2021-03-04 , DOI: 10.1146/annurev-cancerbio-070820-032858
Tushar J. Desai 1
Affiliation  

Lung cancer continues to be the number one cancer killer. Despite a surge of therapeutic advances in recent years, lung cancer remains fatal when it presents at a stage too advanced for surgical resection. In part, this is due to the disappointing reality of inevitable drug resistance in the face of highly effective, mutation-specific chemotherapy and the limited efficacy of immune checkpoint blockade. Yet, with the increasing application and integration of diverse genomic profiling approaches and the advent of high-content single-cell technologies, the mechanisms of lung cancer initiation, evolution, spread, and resistance are being unraveled at unprecedented resolution. Increasingly sophisticated mouse genetic, xenotransplantation, and ex vivo assays are also enabling functional validation and empiric screening of new therapeutic candidates. In this review, I highlight recent insights into the genetic, cellular, and molecular mechanisms of lung cancer and relate them to the normal biology of the developing and mature lung.

中文翻译:


肺癌的发展见解

肺癌仍然是第一大癌症杀手。尽管近年来治疗方法取得了飞速发展,但是当肺癌处于手术切除太晚期的阶段时,它仍然是致命的。在某种程度上,这是由于面对高效,特定于突变的化学疗法以及不可避免的耐药性令人失望的现实,以及免疫检查站封锁的有限功效。然而,随着越来越多的基因组分析方法的应用和集成以及高含量单细胞技术的出现,以前所未有的分辨率揭示了肺癌的发生,发展,扩散和耐药机制。日益复杂的小鼠遗传,异种移植和离体测定也使功能验证和经验筛选新的治疗候选药物成为可能。

更新日期:2021-03-05
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