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Reeling in the Zebrafish Cancer Models
Annual Review of Cancer Biology ( IF 4.7 ) Pub Date : 2021-03-04 , DOI: 10.1146/annurev-cancerbio-051320-014135
Alicia M. McConnell 1, 2, 3 , Haley R. Noonan 1, 2, 3, 4 , Leonard I. Zon 1, 2, 3, 5
Affiliation  

Zebrafish are rapidly becoming a leading model organism for cancer research. The genetic pathways driving cancer are highly conserved between zebrafish and humans, and the ability to easily manipulate the zebrafish genome to rapidly generate transgenic animals makes zebrafish an excellent model organism. Transgenic zebrafish containing complex, patient-relevant genotypes have been used to model many cancer types. Here we present a comprehensive review of transgenic zebrafish cancer models as a resource to the field and highlight important areas of cancer biology that have yet to be studied in the fish. The ability to image cancer cells and niche biology in an endogenous tumor makes zebrafish an indispensable model organism in which we can further understand the mechanisms that drive tumorigenesis and screen for potential new cancer therapies.

中文翻译:


卷入斑马鱼癌症模型

斑马鱼正迅速成为癌症研究的主要模式生物。斑马鱼与人类之间高度保守癌症的遗传途径,而易于操纵斑马鱼基因组以迅速产生转基因动物的能力使斑马鱼成为了出色的模型生物。含有复杂的,与患者有关的基因型的转基因斑马鱼已被用来模拟许多癌症类型。在这里,我们将对转基因斑马鱼癌症模型进行全面综述,以作为该领域的资源,并重点介绍尚未在鱼类中研究的癌症生物学重要领域。对内源性肿瘤中的癌细胞和生态位生物学成像的能力使斑马鱼成为必不可少的模型生物,在其中我们可以进一步了解驱动肿瘤发生的机制并筛选潜在的新癌症疗法。

更新日期:2021-03-05
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