当前位置: X-MOL 学术Annu. Rev. Cancer Biol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Immunometabolism in the Tumor Microenvironment
Annual Review of Cancer Biology ( IF 4.7 ) Pub Date : 2021-03-04 , DOI: 10.1146/annurev-cancerbio-030518-055817
Dominic G. Roy 1 , Irem Kaymak 2 , Kelsey S. Williams 2 , Eric H. Ma 2 , Russell G. Jones 2
Affiliation  

Advances in immunotherapy have underscored the importance of antitumor immune responses in controlling cancer. However, the tumor microenvironment (TME) imposes several obstacles to the proper function of immune cells, including a metabolically challenging and immunosuppressive microenvironment. The increased metabolic activity of tumor cells can lead to the depletion of key nutrients required by immune cells and the accumulation of byproducts that hamper antitumor immunity. Furthermore, the presence of suppressive immune cells, such as regulatory T cells and myeloid-derived suppressor cells, and the expression of immune inhibitory receptors can negatively impact immune cell metabolism and function. This review summarizes the metabolic reprogramming that is characteristic of various immune cell subsets, discusses how the metabolism and function of immune cells are shaped by the TME, and highlights how therapeutic interventions aimed at improving the metabolic fitness of immune cells and alleviating the metabolic constraints in the TME can boost antitumor immunity.

中文翻译:


肿瘤微环境中的免疫代谢

免疫疗法的进步强调了抗肿瘤免疫反应在控制癌症中的重要性。但是,肿瘤微环境(TME)对免疫细胞的正常功能施加了一些障碍,包括代谢困难和免疫抑制的微环境。肿瘤细胞代谢活性的增强可导致免疫细胞所需的关键营养物质耗尽,并阻碍了抗肿瘤免疫力的副产物的积累。此外,抑制性免疫细胞(例如调节性T细胞和髓样来源的抑制性细胞)的存在以及免疫抑制受体的表达可能会对免疫细胞的代谢和功能产生负面影响。这篇综述总结了各种免疫细胞亚群所特有的代谢重编程,

更新日期:2021-03-05
down
wechat
bug