Abstract

Objectives

We aimed to investigate the effects of asprosin on diabetes with a focus on serum glucose, irisin, ghrelin, leptin levels and hepatic levels of triglycerides (TG), cholesterol, low-density lipoprotein (LDL).

Methods

Asprosin (10 µg/kg) was administered intraperitoneally four times at 3-day intervals and then blood and hepatic parameters above mentioned were investigated in control and diabetic mice.

Results

The administration of asprosin increased blood glucose level in healthy animals (p = .05) whereas it did not change blood glucose level in diabetic animals. In addition, while asprosin decreased irisin level and increased ghrelin level, it did not change leptin level in diabetic mice. Therewithal, asprosin decreased the increasing levels in hepatic TG, cholesterol, and LDL in diabetic mice.

Conclusions

Our novel findings implicate that asprosin may be a target molecule in preventing the development and complications of diabetes.

中文翻译：

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白脂素，一种新型生糖脂肪因子：糖尿病的潜在治疗意义

摘要

目标

我们的目的是研究白脂素对糖尿病的影响，重点关注血糖、鸢尾素、生长素释放肽、瘦素水平以及甘油三酯 (TG)、胆固醇、低密度脂蛋白 (LDL) 的肝脏水平。

方法

以 3 天的间隔腹腔注射白脂素 (10 µg/kg) 四次，然后在对照小鼠和糖尿病小鼠中研究上述血液和肝脏参数。

结果

给予白脂素会增加健康动物的血糖水平 ( p  = .05)，而不会改变糖尿病动物的血糖水平。此外，虽然白脂素降低了鸢尾素水平并增加了生长素释放肽水平，但它并没有改变糖尿病小鼠的瘦素水平。此外，白脂素降低了糖尿病小鼠肝脏 TG、胆固醇和 LDL 水平的升高。

结论

我们的新发现表明白脂素可能是预防糖尿病发展和并发症的靶分子。