In the past decades, the application of on-line high performance liquid chromatography coupled with gas chromatography (HPLC-GC) has been rapidly developed for the quantitative analysis of mineral oil hydrocarbons (MOH). MOH are derived from petroleum and synthetic fuels, and cover a large range of boiling points, mainly consisting of mineral oil saturated hydrocarbons (MOSH) and aromatic hydrocarbons (MOAH). MOH can migrate into food and environment through a variety of pathways, consequently impose an adverse impact on human health. However, the analysis of MOH is challenging due to the limited selectivity and sensitivity of hydrogen flame ionization detector (FID). On-line HPLC-GC combines the high separation efficiency of HPLC with the equal-carbon-response detection of GC-FID, which solves the problems associated with selectivity and sensitivity of MOH analysis. The innovation of the retention gap, Y-piece interface, and solvent vapor exit (SVE) with which the HPLC-GC is equipped enables large-volume injection into GC-FID. By allowing the elution fractions from HPLC to be completely transferred into the GC, the analytical sensitivity of the MOH is enhanced by more than two orders of magnitude, and the contaminants introduced are minimized during the analytical procedure, ensuring the reproducibility and accuracy of the MOH analysis. In this paper, the research history of the interfaces used in on-line HPLC-GC and the matching conditions between HPLC and GC were described in detail, and the sample preparation methods for the removal of interferences and the enrichment of MOH based on HPLC-GC were reviewed. In addition, the limitations of HPLC-GC were summarized, and the future applications of this technology and the trends in the development of MOH analysis were prospected.

在过去的几十年中，在线高效液相色谱结合气相色谱（HPLC-GC）的应用已迅速发展，用于矿物油烃（MOH）的定量分析。MOH衍生自石油和合成燃料，沸点范围很大，主要由矿物油饱和烃（MOSH）和芳烃（MOAH）组成。卫生部可以通过多种途径迁移到食品和环境中，从而对人类健康产生不利影响。但是，由于氢火焰离子化检测器（FID）的选择性和灵敏度有限，因此MOH的分析具有挑战性。在线HPLC-GC将HPLC的高分离效率与GC-FID的等碳响应检测结合在一起，解决了与MOH分析的选择性和敏感性相关的问题。HPLC-GC配备的保留间隙，Y形件界面和溶剂蒸气出口（SVE）的创新，可实现向GC-FID的大量进样。通过将HPLC洗脱部分完全转移到GC中，MOH的分析灵敏度提高了两个数量级以上，并且在分析过程中将引入的污染物减至最少，从而确保了MOH的重现性和准确性分析。本文详细介绍了在线HPLC-GC所用接口的研究历史以及HPLC和GC之间的匹配条件，并介绍了基于HPLC-GC去除干扰和富集MOH的样品制备方法。气相色谱进行了审查。此外，