Bisphenol A [BPA; (CH₃)₂C(C₆H₄OH)₂] is a synthetic chemical used as a precursor material for the manufacturing of plastics and resins. It gained attention due to its high chances of human exposure and predisposing individuals at extremely low doses to diseases, including cancer. It enters the human body via oral, inhaled, and dermal routes as leach-out products. BPA may be anticipated as a probable human carcinogen. Studies using in vitro cell lines, rodent models, and epidemiological analysis have convincingly shown the increasing susceptibility to cancer at doses below the oral reference dose set by the Environmental Protection Agency for BPA. Furthermore, BPA exerts its toxicological effects at the genetic and epigenetic levels, influencing various cell signaling pathways. The present review summarizes the available data on BPA and its potential impact on cancer and its clinical outcome.

双酚 A [BPA; (CH ₃ ) ₂ C(C ₆ H ₄ OH) ₂] 是一种合成化学品，用作制造塑料和树脂的前体材料。它因其人类接触的高机会和极低剂量的个体易患疾病（包括癌症）而受到关注。它作为浸出产品通过口服、吸入和皮肤途径进入人体。BPA 可能被认为是一种可能的人类致癌物。使用体外细胞系、啮齿动物模型和流行病学分析的研究令人信服地表明，在低于环境保护局为 BPA 设定的口服参考剂量的剂量下，对癌症的易感性增加。此外，BPA 在遗传和表观遗传水平上发挥其毒理学作用，影响各种细胞信号通路。