Abstract

Under conditions of lymphopenia, T lymphocytes proliferate and acquire a surface activation phenotype, which in many respects is similar to the phenotype of true memory T cells. We investigated the phenotypic features of the CD8+ T-cell population formed from donor lymphocytes after adoptive transfer of syngeneic splenocytes to sublethally irradiated mice. This population expresses markers CD44, CD122, CD5, CD49d and the chemokine receptor CXCR3. Thus, for the first time, the phenomenon of the formation of a population of T cells with signs of suppressive CD8+ T lymphocytes and true memory cells was demonstrated.

中文翻译：

---

将同基因脾细胞过继转移给淋巴细胞减少症小鼠后，形成独特的 CD8+ T 淋巴细胞群

摘要

在淋巴细胞减少的情况下，T淋巴细胞增殖并获得表面活化表型，这在许多方面与真实记忆T细胞的表型相似。我们研究了在将同系脾细胞过继转移到亚致死照射小鼠后由供体淋巴细胞形成的 CD8+ T 细胞群的表型特征。该群体表达标记物 CD44、CD122、CD5、CD49d 和趋化因子受体 CXCR3。因此，首次证明了形成具有抑制性 CD8+ T 淋巴细胞和真正记忆细胞迹象的 T 细胞群的现象。