Patients with anorexia nervosa (AN) often experience low bone mineral density (BMD) and increased fracture risk, with low body weight and decreased gonadal function being the strongest predictors of the observed bone mineral deficit and fractures. Other metabolic disturbances have also been linked to bone loss in this group of patients, including growth hormone resistance, low insulin-like growth factor-1 (IGF-1) concentrations, low leptin concentrations, and hypercortisolemia. However, these correlations lack definitive evidence of causality. Weight restoration and resumption of menstrual function have the strongest impact on increasing BMD. Other potential treatment options include bisphosphonates and teriparatide, supported by data from small clinical trials, but these agents are not approved for the treatment of low BMD in adolescents or premenopausal women with AN.

患有神经性厌食症 (AN) 的患者经常经历低骨矿物质密度 (BMD) 和骨折风险增加，低体重和性腺功能下降是观察到的骨矿物质缺乏和骨折的最强预测因素。其他代谢紊乱也与这组患者的骨质流失有关，包括生长激素抵抗、低胰岛素样生长因子-1 (IGF-1) 浓度、低瘦素浓度和高皮质醇血症。然而，这些相关性缺乏因果关系的明确证据。体重恢复和月经功能恢复对增加 BMD 的影响最大。其他潜在的治疗选择包括双膦酸盐和特立帕肽，得到小型临床试验数据的支持，