Neonatal jaundice occurs in >80% of newborns in the first week of life owing to physiological hyperbilirubinemia. Severe hyperbilirubinemia could cause brain damage owing to its neurotoxicity, a state commonly known as kernicterus. Therefore, periodic bilirubin monitoring is essential to identify infants at-risk and to initiate treatment including phototherapy. However, devices for continuous measurements of bilirubin have not been developed yet. Here, we established a wearable transcutaneous bilirubinometer that also has oxygen saturation (SpO₂) and heart rate (HR) sensing functionalities. Clinical experiments with neonates demonstrated the possibility of simultaneous detection of bilirubin, SpO₂, and HR. Moreover, our device could consistently measure bilirubin during phototherapy. These results demonstrate the potential for development of a combined treatment approach with an automatic link via the wearable bilirubinometer and phototherapy device for optimization of the treatment of neonatal jaundice.

由于生理性高胆红素血症，>80% 的新生儿在出生后第一周会出现新生儿黄疸。严重的高胆红素血症可能因其神经毒性而导致脑损伤，这种状态通常称为核黄疸。因此，定期监测胆红素对于识别高危婴儿并开始包括光疗在内的治疗至关重要。然而，用于连续测量胆红素的装置尚未开发出来。在这里，我们建立了一种可穿戴式经皮胆红素计，它还具有氧饱和度 (SpO ₂ ) 和心率 (HR) 传感功能。新生儿临床实验证明了同时检测胆红素、SpO ₂和 HR 的可能性。此外，我们的设备可以在光疗期间持续测量胆红素。这些结果证明了通过可穿戴胆红素计和光疗设备自动连接开发联合治疗方法的潜力，以优化新生儿黄疸的治疗。