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Quercetin as a Precursor for the Synthesis of Novel Nanoscale Cu (II) Complex as a Catalyst for Alcohol Oxidation with High Antibacterial Activity
Bioinorganic Chemistry and Applications ( IF 3.8 ) Pub Date : 2021-03-04 , DOI: 10.1155/2021/8818452
Zahra Moodi 1 , Ghodsieh Bagherzade 1 , Janny Peters 2
Affiliation  

Quercetin (3,3′,4′,5,7-pentahydroxyflavone) is one of the dietary flavonoids, distributed in medicinal plants, vegetables, and fruits. Quercetin has the ability to bind with several metal ions to increase its biological activities. In the last two decades, quercetin has attracted considerable attention due to the biological and pharmaceutical activities such as antioxidant, antibacterial, and anticancer. In the present study, quercetin and ethanolamine were used for the synthesis Schiff base complex, which was characterized by IR, 1H NMR, and 13C NMR spectroscopy. The Schiff base has been employed as a ligand for the synthesis of novel nanoscale Cu (II) complex. The product was characterized by FT-IR spectroscopy, FESEM, and XRD. Significantly, the product showed remarkable catalytic activity towards the oxidation of primary and secondary alcohols. The antibacterial activity of the final product was assessed against Staphylococcus aureus (Gram‐positive) and Escherichia coli (Gram‐negative) bacteria using an inhibition zone test. The synthesized nanoscale Cu (II) complex exhibited a strong antibacterial activity against both Gram-positive and Gram-negative bacteria.

中文翻译:

槲皮素作为前体,用于合成新型纳米级Cu(II)配合物作为具有高抗菌活性的醇氧化催化剂

槲皮素(3,3',4',5,7-五羟基黄酮)是一种膳食类黄酮,分布于药用植物,蔬菜和水果中。槲皮素具有与几种金属离子结合的能力,以增强其生物活性。在过去的二十年中,由于抗氧化剂,抗菌剂和抗癌剂等生物和药物活性,槲皮素引起了相当大的关注。在本研究中,槲皮素和乙醇胺用于合成席夫碱配合物,其特征在于IR,1 H NMR和1313 C NMR光谱。Schiff碱已被用作合成新型纳米级Cu(II)配合物的配体。通过FT-IR光谱,FESEM和XRD对产物进行表征。重要的是,该产物对伯醇和仲醇的氧化显示出显着的催化活性。使用抑制区测试评估了最终产品对金黄色葡萄球菌(革兰氏阳性)和大肠杆菌(革兰氏阴性)细菌的抗菌活性。合成的纳米级Cu(II)配合物对革兰氏阳性和革兰氏阴性细菌均表现出强大的抗菌活性。
更新日期:2021-03-04
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