Background: While bariatric surgery could result in weight loss as well as glycaemia improvement, the short-term impact on bone health in a high glycemic environment following Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) remains intriguing. Objective: The aim of this study was to compare the short-term effects of RYGB and SG procedures on bone health in Zucker diabetic fatty (ZDF^fa/fa) rats. Methods: Thirty age-matched male ZDF^fa/fa rats were randomized into RYGB, SG, and sham groups after establishment of the diabetic model. Body weight, blood glucose, bone mineral density (BMD), the level of bone turnover markers (BTM), vitamin D, and serum calcium and phosphorus were measured 4 weeks after the operation. Results: The RYGB procedure brought about lower blood glucose, BMD, serum calcium and phosphorus levels, as well as a relatively higher bone turnover rate and 1,25(OH)₂VD level, compared to the SG and sham groups, while the influences of the SG procedure were not significant. 25(OH)VD demonstrated no significant difference among the 3 groups. Conclusions: Despite its excellent ability to provide short-term glycemic control, the RYGB procedure could led to more severe impairment of bone health compared to the SG procedure. Bone health should be procured after bariatric surgery, especially with the RYGB procedure. Early detection of BMD and BTM may help to avoid deterioration of bone.
Obes Facts

中文翻译：

---

Roux-en-Y 胃绕道术和袖状胃切除术对 Zucker 糖尿病肥胖大鼠骨矿物质密度的影响：一项短期比较研究

背景：虽然减肥手术可以减轻体重并改善血糖，但 Roux-en-Y 胃绕道手术 (RYGB) 和袖状胃切除术 (SG) 后在高血糖环境下对骨骼健康的短期影响仍然令人着迷。目的：^{本研究的目的是比较 RYGB 和 SG 手术对 Zucker 糖尿病肥胖 (ZDF fa/fa} ​​) 大鼠骨骼健康的短期影响方法：将30只年龄匹配的雄性ZDF ^fa/fa大鼠糖尿病模型建立后随机分为RYGB组、SG组和假手术组。术后4周测定体重、血糖、骨密度（BMD）、骨转换标志物（BTM）、维生素D、血清钙、磷水平。结果：与SG组和假手术组相比，RYGB手术带来较低的血糖、BMD、血清钙和磷水平，以及相对较高的骨转换率和1,25(OH) ₂ VD水平，而影响SG 程序的影响并不显着。25(OH)VD 在三组之间没有显着差异。结论：尽管 RYGB 手术具有出色的短期血糖控制能力，但与 SG 手术相比，它可能会导致更严重的骨骼健康损害。减肥手术后应保持骨骼健康，尤其是 RYGB 手术后。早期检测 BMD 和 BTM 可能有助于避免骨骼退化。
肥胖事实