Background & aims

Schizophrenia is a serious long-term disorder in which the metabolic complications and abnormalities of the brain-derived neurotrophic factor (BDNF) can be found. In this study, we conducted a systematic review of the relationship between BDNF, metabolic syndrome (MetS) and its components in schizophrenic patients.

Methods

Data were collected mainly from PubMed, Google Scholar, Scopus, and ProQuest databases. The keywords related to the BDNF, MetS, schizophrenia were searched. Two reviewers independently screened 1061 abstracts. And eventually, a total of 7 studies (6 observational and 1 interventional) was included in the systematic reviews.

Results

Four of the 7 study ascertained statistically significant inverse relationship between serum BDNF levels and MetS in schizophrenic patients. While in the other two studies, there was no inverse relationship. In the last selected study, the researchers found a weak association between the Val66Met polymorphism in BDNF Gene and clozapine-induced MetS.

Conclusion

Although this relationship could not be determined but BDNF levels appear to be reduced in schizophrenic patients with MetS and factors such as sex and antipsychotic class differentiation, sampling and methodology and episodes of illness could play a role in the results and outcomes.

中文翻译：

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慢性精神分裂症患者脑源性神经营养因子与代谢综合征的关系：系统评价

背景与目标

精神分裂症是一种严重的长期疾病，其中可以发现脑源性神经营养因子（BDNF）的代谢并发症和异常。在这项研究中，我们对精神分裂症患者的 BDNF、代谢综合征 (MetS) 及其成分之间的关​​系进行了系统评价。

方法

数据主要来自 PubMed、Google Scholar、Scopus 和 ProQuest 数据库。搜索与BDNF、MetS、精神分裂症相关的关键词。两名审稿人独立筛选了 1061 篇摘要。最终，共有 7 项研究（6 项观察性研究和 1 项介入性研究）被纳入系统评价。

结果

7 项研究中有 4 项确定了精神分裂症患者血清 BDNF 水平与 MetS 之间具有统计学意义的负相关。而在另外两项研究中，没有反比关系。在最后一项选定的研究中，研究人员发现 BDNF 基因中的 Val66Met 多态性与氯氮平诱导的 MetS 之间存在弱关联。

结论

尽管无法确定这种关系，但患有 MetS 的精神分裂症患者的 BDNF 水平似乎降低，并且性别和抗精神病药物类别分化、采样和方法以及疾病发作等因素可能在结果和结果中发挥作用。