Abstract

The aggregation behavior, solubilization effect, and catalytic activity of hexadecylpiperidinium surfactants (including ones functionalized with hydroxyl substituents) have been investigated. The kinetics of hydrolytic cleavage of the irreversible cholinesterase inhibitor ethyl p-nitrophenyl ethylphosphonate (armine) in the micellar solutions of these surfactants has been studied using spectrophotometry. It has been shown that the micellar catalytic effect increases in the following order: methyl(hexadecyl)piperidinium bromide < methyl(hexadecyl)-3-hydroxypiperidinium bromide < hexadecyl(2-hydroxyethyl)piperidinium bromide < 2-hydroxyethyl-4-hydroxypiperidinium bromide. The acceleration observed can be as high as almost two orders of magnitude.

中文翻译：

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基于羟基哌啶表面活性剂的胶束体系在对硝基苯基膦酸酯水解中的催化作用

摘要

研究了十六烷基哌啶表面活性剂（包括用羟基取代基官能化的表面活性剂）的聚集行为，增溶效果和催化活性。使用分光光度法研究了在这些表面活性剂的胶束溶液中不可逆胆碱酯酶抑制剂对硝基苯基乙基膦酸乙酯（芳胺）的水解裂解动力学。已经表明，胶束催化作用按以下顺序增加：甲基（十六烷基）哌啶溴＜甲基（十六烷基）-3-羟基哌啶溴＜十六烷基（2-羟基乙基）哌啶溴＜2-羟基乙基-4-羟基哌啶溴。观察到的加速度可能高达近两个数量级。