Abstract

To optimize the phase separation temperature of poly (N-isopropylacrylamide) two monomers have been used to fabricate a series of three functional and thermo-pH terpolymers. N-(2-(dimethylamino)ethyl)acrylamide (DMAEAm) acts as a hydrophilic and pH-responsive monomer and 4-formyl-2-methoxyphenylacrylate or vanillin acrylate (VA) as hydrophobic and functional monomer both monomers have been synthesized in a one-step reaction. They were investigated by 1H, 13C NMR, and FTIR and demonstrated good agreement with their chemical structures. Dual responsive functional terpolymers have been fabricated in different molar ratios of (DMAEAm) (10, 15, and 20 mol%) with 10 mol% of VA; they have been investigated by chemical methods such as 1H, and FTIR as well. The physical characterization has also been achieved using GPC for molecular weight and molecular weight distributions, DSC for glass transition temperature. The vital point is studying the phase separation temperature or the lower critical solution temperature of the polymer solution, and the relative influence of DMAEAm and VA on transition temperature T_c of terpolymer solution; it has been recorded by turbidity test using UV–Vis-spectroscopy as the change of transmittance with temperature, on the other hand using micro-DSC of the polymer solution was tested. This optimization in the poly (NIPAAm) characterization encourages the application of the new terpolymer as a biosensor.

Graphic Abstract

中文翻译：

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聚（N-异丙基丙烯酰胺-co-N-（2-（二甲基氨基）乙基）丙烯酰胺-香草醛丙烯酸酯）的功能性和pH响应性三元共聚物的相分离温度优化的趋势

摘要

为了优化聚（N-异丙基丙烯酰胺）的相分离温度，已使用两种单体来制造一系列三种功能性和热pH三元共聚物。N-（2-（二甲基氨基）乙基）丙烯酰胺（DMAEAm）充当亲水性和pH响应单体，4-甲氧基-2-甲氧基苯基丙烯酸酯或香草醛丙烯酸酯（VA）充当疏水性和功能性单体，两种单体均已在一个单体中合成步骤反应。通过1 H，13 C NMR和FTIR对它们进行了研究，并证明它们与它们的化学结构吻合良好。已经以不同摩尔比的（DMAEAm）（10、15和20mol％）与10mol％的VA制备了双响应功能性三元共聚物。它们已经通过化学方法（例如1H和FTIR）进行了研究。使用GPC进行分子量和分子量分布，DSC进行玻璃化转变温度也可以实现物理表征。关键是研究相分离温度或聚合物溶液的下临界溶液温度，以及DMAEAm和VA对转变温度的相对影响。三元共聚物溶液的T _c；通过使用紫外-可见光谱的浊度测试记录了它的透射率随温度的变化，另一方面，使用了聚合物溶液的micro-DSC进行了测试。聚（NIPAAm）表征的这种优化鼓励了新型三元共聚物作为生物传感器的应用。

图形摘要