Apoptosis is a sequential order of cell death occurring regularly to ensure a homeostatic balance between the rate of cell formation and cell death. However, a misplaced of this balancing function can contribute to an abnormal cell growth / proliferation or autoimmune disorders etc. Apoptosis is therefore said to be crucial from the point of development of an embryo throughout the growth of an organism contributing to the renewal of tissues and also the getting rid of inflammatory cells. This review seeks to elaborate on the recent overview of the mechanism involved in apoptosis, some element and signal contributing to its function and inhibition together with how their malfunction contribute to a number of cancer related cases.

中文翻译：

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凋亡（程序性细胞死亡）及其信号-综述

凋亡是定期发生的细胞死亡的顺序，以确保细胞形成速率与细胞死亡之间的体内平衡。但是，这种平衡功能的错位会导致异常的细胞生长/增殖或自身免疫性疾病等。因此，从胚胎发育的角度来看，在整个生物体生长过程中，细胞凋亡是至关重要的，这有助于组织和组织的更新。也摆脱了炎症细胞。这篇综述试图详细阐述凋亡相关机制的概述，一些有助于其功能和抑制的元素和信号以及它们的功能异常如何导致许多与癌症相关的病例。