A series of asymmetrical 4-alkyl/aryl-2,6-dimethyl-3-N-(aryl/heteroaryl)-carbamoyl-5-ethoxycarbonyl-1, 4-dihydropyridines 3a-d and symmetrical 4-alkyl/aryl-2,6-dimethyl-3,5-bis-(ethoxycarbonyl)-1,4-dihydropyridines 4a and 4b have been prepared by the condensation of various benzaldehydes, ethylacetoacetate, 2-aminopyridine or p-toludine in ethanol (Hantzch method). The structures of all the synthesized 1,4-dihydropyridine derivatives have been confirmed by spectral data (IR, ¹H NMR) and elemental analysis. Compounds 3a-c, 4a and 4b (10 mg/kg) have been evaluated for their anticonvulsant effect against pentylenetetrazole- induced convulsions with phenytoin (4 mg/kg) as the standard. The anticonvulsant potential of the newly synthesized compounds have been assessed on the basis of increase in latency (onset time) to induce convulsions; decrease in number of convulsions and increase in latency of death compared to control and standard.

中文翻译：

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1,4-二氢吡啶衍生物的合成及其抗惊厥活性

一系列不对称的4-烷基/芳基-2,6-二甲基-3-N-（芳基/杂芳基）-氨基甲酰基-5-乙氧基羰基-1、4-二氢吡啶3a-d和对称的4-烷基/芳基-2， 6-二甲基-3，5-双-（乙氧羰基）-1，4-二氢吡啶4a和4b是通过将各种苯甲醛，乙酰乙酸乙酯，2-氨基吡啶或对甲苯胺在乙醇中缩合制备的（Hantzch方法）。所有合成的1,4-二氢吡啶衍生物的结构已通过光谱数据（IR，¹ H NMR）和元素分析得到证实。化合物3a-c，4a和4b以苯妥英（4 mg / kg）为标准，已评估（10 mg / kg）对戊戊四唑诱导的惊厥的抗惊厥作用。新合成化合物的抗惊厥潜能已根据诱发惊厥的潜伏期（发作时间）的增加进行了评估。与对照组和标准组相比，惊厥次数减少，死亡潜伏期延长。