In the present investigation, a series of 3-aryl-4-methoxy N-alkyl maleimide 5a-l have been synthesized and screened for their antimicrobial activity against one Gram positive bacteria (S. aureus), one Gram negative bacteria (E. coli) and fungal strains (C. albicans, C. tropicalis,  A. niger and A. clavatus). The structures of the compounds have been substantiated by their IR, NMR, mass and elemental analysis. The minimum inhibitory concentrations (MICs) of synthesized maleimides have been determined by broth microdilution method. Of the newly synthesized maleimides, compounds 5c, 5f, 5h, 5i, 5k and 5l registered significant activity against the tested microorganisms.

中文翻译：

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新型3-芳基-4-甲氧基N-烷基马来酰亚胺的合成与生物学评价

在本研究中，已合成了一系列3-芳基-4-甲氧基N-烷基马来酰亚胺5a-1，并筛选了它们对一种革兰氏阳性细菌（金黄色葡萄球菌），一种革兰氏阴性细菌（大肠杆菌）的抗菌活性。）和真菌菌株（白色念珠菌，热带念珠菌，  黑曲霉和棒曲霉）。化合物的结构已通过其IR，NMR，质量和元素分析得到证实。合成的马来酰亚胺的最低抑菌浓度（MICs）已通过肉汤微稀释法确定。在新合成的马来酰亚胺中，化合物5c，5f，5h，5i，5k和5l对被测微生物具有明显的活性。