In recent years, the thioisatin (benzo[b]thiophene-2,3-diones) have attracted considerable attention due to their ability to act as intermediates in the preparation of a series of fused spiroheterocycles. The benzothiophenic frameworks are important targets in synthetic and medicinal chemistry because this fragment is a key moiety in a wide number of natural and synthetic agents. Subsequently the present study deals with the synthesis of a variety of spiroheterocycles for which different strategies have been evolved viz. [4+2] photocycloaddition (spiropyrans), cyclocondensation (benzodiazocine), nucleophilic cyclization (spirothioazolidinones) and air oxidation (disulfides). semicarbazide reacts with thioisatin at 3‑position (thiosemicarbazones, 2-hydroxy-(2H)-3,3-diaryl- and 3-hydroxy-3H-2,2-diaryl-benzo[b]thiophenes hydroxyl compounds), 4,9-dimethylthiophanthrenes.

中文翻译：

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简短的评论：硫代他汀及其衍生物的化学

近年来，由于硫磺素（苯并[b]噻吩-2,3-二酮）在制备一系列稠合的螺杂环化合物中起中间体的作用，因此引起了相当大的关注。苯并噻吩骨架是合成和药物化学中的重要目标，因为该片段是多种天然和合成试剂中的关键部分。随后，本研究涉及各种螺杂环化合物的合成，针对这些螺杂环化合物已发展出不同的策略。[4 + 2]光环加成（螺吡喃），环缩合（苯并重氮），亲核环化（螺硫代偶氮酮）和空气氧化（二硫化物）。氨基脲与硫代异黄素在3位反应（硫代氨基脲，2-羟基-（2 H）-3，3-二芳基-和3-羟基-3 H -2，2-二芳基-苯并[b]噻吩羟基化合物），4，9-二甲基硫杂蒽。