A series of mononuclear organoantimony(III) and organoarsenic(III) complexes of bidentate Schiff base [2-(2-fluorophenyl)methylene]hydrazinecarbothioamide (LH) have been synthesized by the reaction of Ph₃Sb and Ph₃As with ligand in 1:1 and 1:2 molar ratios. All the synthesized compounds were characterized by elemental analyses, melting point determinations and a combination of electronic, IR, ¹H NMR, ¹³C NMR and X-ray diffraction studies. These studies have shown that the ligand coordinated to the antimony and arsenic in a monobasic bidentate manner through sulfur and nitrogen donor system. Thus, a tetra-coordinated and a penta-coordinated environment around the antimony and arsenic atom have been proposed for 1:1 and 1:2 complexes, respectively. All the complexes and parent ligand have been screened for their antimicrobial activity on several pathogenic fungi and bacteria and are found to possess appreciable fungicidal and bactericidal properties. Further, the ligand and its corresponding metal complexes have been tested for their DNA cleavage activity by the gel electrophoresis and the results revealed that the complexes are better cleaving agents than ligand.

中文翻译：

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具有单官能双齿席夫碱的有机锑（III）和有机砷（III）配合物的合成，表征，抗菌和DNA裂解研究

通过Ph ₃ Sb和Ph ₃ As与配体在1中反应，合成了一系列双齿席夫碱席夫碱[2-（2-氟苯基）亚甲基]肼基碳硫磺酰胺（LH）的单核有机锑（III）和有机砷（III）配合物。1：1和1：2的摩尔比。所有合成的化合物均通过元素分析，熔点测定以及电子，IR，¹ H NMR，¹³的组合进行表征C NMR和X射线衍射研究。这些研究表明，配体通过硫和氮供体系统以二元二齿方式与锑和砷配位。因此，已经针对锑和砷原子分别提出了四配位和五配位的环境。筛选了所有复合物和母体配体对几种病原真菌和细菌的抗菌活性，发现它们具有明显的杀真菌和杀菌性能。此外，已经通过凝胶电泳测试了配体及其相应的金属配合物的DNA切割活性，结果表明，该配合物比配体是更好的切割剂。