Modifications of protein, RNA and DNA play an important role in many biological processes and are related to some diseases. Therefore, accurate identification and comprehensive understanding of protein, RNA and DNA modification sites can promote research on disease treatment and prevention. With the development of sequencing technology, the number of known sequences has continued to increase. In the past decade, many computational tools that can be used to predict protein, RNA and DNA modification sites have been developed. In this review, we comprehensively summarized the modification site predictors for three different biological sequences and the association with diseases. The relevant web server is accessible at http://lab.malab.cn/∼acy/PTM_data/ some sample data on protein, RNA and DNA modification can be downloaded from that website.

中文翻译：

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生物序列修饰的预测及其与疾病的关联

蛋白质、RNA 和 DNA 的修饰在许多生物过程中起着重要作用，并与一些疾病有关。因此，准确识别和全面了解蛋白质、RNA和DNA修饰位点可以促进疾病治疗和预防的研究。随着测序技术的发展，已知序列的数量不断增加。在过去的十年中，已经开发了许多可用于预测蛋白质、RNA 和 DNA 修饰位点的计算工具。在这篇综述中，我们全面总结了三种不同生物序列的修饰位点预测因子以及与疾病的关联。相关的网络服务器可在 http://lab.malab.cn/∼acy/PTM_data/ 访问，一些关于蛋白质、RNA 和 DNA 修饰的样本数据可以从该网站下载。