SummaryDicliptera verticillata is a medicinal plant traditionally used in western Cameroon to cure female infertility. This experiment was designed to assess the effects of the aqueous extract of Dicliptera verticillata (AEDv) on fertility and gestation in female rats. Oral increasing doses of AEDv were administered to immature female rats over 20 d. After this time, some animals were mated with fertile males and some fertility parameters were assayed; the other animals were euthanized for preliminary toxicity parameters analysis. The effects of AEDv on the different stages of gestation were assayed on selected animals previously controlled for estrous cycle regularity and mated. AEDv led to an increase in serum, uterine and ovarian proteins as well as in ovarian and uterine weights (P < 0.05) in immature female rats. Hepatic proteins significantly decreased (P < 0.01) in high dose-treated animals (50 and 100 mg/kg) compared with controls. The number of implantation sites and the fertility rate were significantly lower (P < 0.05), while the antifertility activity increased significantly (P < 0.05) in treated rats compared with controls. When administered from the 1st to the 5th day of pregnancy, AEDv led to a decrease of more than 60% in the implantation rate in high dose-treated rats (50, 100, and 400 mg/kg). From the 6th to the 9th day, the implantation, gestation rates and the number of fetuses decreased significantly in all treated groups. From the 11th to the 20th day, a 50% resorption and decrease in gestation rate were reported in 50 mg/kg dose-treated animals. AEDv possesses weak contraceptive and abortifacient effects during pregnancy.

中文翻译：

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黄花菜水提物对雌性大鼠生育力及妊娠不同阶段的影响

概括轮叶双翅目是一种传统上在喀麦隆西部用于治疗女性不育症的药用植物。本实验旨在评估水提物的效果轮叶双翅目(AEDv) 对雌性大鼠生育力和妊娠的影响。未成熟雌性大鼠口服增加剂量的 AEDv 超过 20 天。在这段时间之后，一些动物与有生育能力的雄性交配，并测定了一些生育参数；对其他动物实施安乐死以进行初步毒性参数分析。在先前控制发情周期规律和交​​配的选定动物身上测定了 AEDv 对妊娠不同阶段的影响。AEDv 导致血清、子宫和卵巢蛋白以及卵巢和子宫重量增加（磷< 0.05) 在未成熟的雌性大鼠中。肝蛋白显着减少（磷< 0.01) 在高剂量处理的动物（50 和 100 mg/kg）中与对照组相比。着床点数和生育率显着降低（磷< 0.05），而抗生育活性显着增加（磷< 0.05) 治疗大鼠与对照组相比。在妊娠第 1 天至第 5 天给药时，AEDv 导致高剂量（50、100 和 400 mg/kg）大鼠的着床率降低 60% 以上。从第6天到第9天，所有治疗组的着床率、妊娠率和胎儿数量均显着下降。从第 11 天到第 20 天，在 50 mg/kg 剂量治疗的动物中报告了 50% 的再吸收和妊娠率降低。AEDv 在怀孕期间具有较弱的避孕和堕胎作用。