Due to extremely severe morbidity and mortality worldwide, it is worth achieving a more in-depth and comprehensive understanding of cardiovascular diseases. Tremendous effort has been made to replicate the cardiovascular system and investigate the pathogenesis, diagnosis and treatment of cardiovascular diseases. Microfluidics can be used as a versatile primary strategy to achieve a holistic picture of cardiovascular disease. Here, a brief review of the application of microfluidics in comprehensive cardiovascular disease research is presented, with specific discussions of the characteristics of microfluidics for investigating cardiovascular diseases integrally, including the study of pathogenetic mechanisms, the development of accurate diagnostic methods and the establishment of therapeutic treatments. Investigations of critical pathogenetic mechanisms for typical cardiovascular diseases by microfluidic-based organ-on-a-chip are categorized and reviewed, followed by a detailed summary of microfluidic-based accurate diagnostic methods. Microfluidic-assisted cardiovascular drug evaluation and screening as well as the fabrication of novel delivery vehicles are also reviewed. Finally, the challenges with and outlook on further advancing the use of microfluidics technology in cardiovascular disease research are highlighted and discussed.

由于全世界范围内极其严重的发病率和死亡率，值得对心血管疾病进行更深入和全面的了解。人们在复制心血管系统以及研究心血管疾病的发病机制、诊断和治疗方面付出了巨大的努力。微流控可作为一种通用的主要策略来全面了解心血管疾病。本文简要回顾了微流控技术在心血管疾病综合研究中的应用，具体讨论了微流控技术在心血管疾病综合研究中的特点，包括发病机制的研究、精准诊断方法的发展以及治疗药物的建立等。治疗。对基于微流控芯片器官疾病的典型心血管疾病关键发病机制的研究进行了分类和综述，并详细总结了基于微流控的精确诊断方法。还回顾了微流体辅助心血管药物的评估和筛选以及新型输送载体的制造。最后，强调并讨论了进一步推进微流控技术在心血管疾病研究中的应用所面临的挑战和前景。