Abstract

There are good evidences suggesting that endoplasmic reticulum (ER) stress can be one of the contributing factors in the development of diabetic retinopathy. The present study was designed to investigate the effect of chemical chaperone 4-phenylbutyric acid (4-PBA) in alleviating the ER stress, and diabetic retinopathy in type 2 diabetic rats. Treatment of diabetic rats with 4-PBA, increased the antioxidant capacity, reduced the levels of lipid peroxidation, organised the state of apoptosis and regulated the ER stress – oxidative activation in retinal tissue. Also there was an improvement in the histological picture of retinal specimens compared to untreated diabetic rats. It was concluded that 4-PBA is a promising therapeutic agent for ER stress diseases such as diabetic retinopathy.

摘要

有充分的证据表明内质网（ER）应激可能是糖尿病视网膜病变发生的影响因素之一。本研究旨在探讨化学伴侣 4-苯基丁酸 (4-PBA) 在缓解 2 型糖尿病大鼠 ER 应激和糖尿病视网膜病变方面的作用。用 4-PBA 治疗糖尿病大鼠，可提高抗氧化能力，降低脂质过氧化水平，组织细胞凋亡状态并调节 ER 应激（视网膜组织中的氧化激活）。与未经治疗的糖尿病大鼠相比，视网膜标本的组织学图像也有所改善。结论是4-PBA是一种很有前景的治疗糖尿病视网膜病变等ER应激疾病的药物。