ABSTRACT

Objectives: With increasing treatment choices for inflammatory bowel disease (IBD), patients’ preferences should be considered to limit non-adherence. We explored patients’ preferences for route, form and frequency of medication administration, and factors influencing these choices.

Methods: Patients rated acceptability of different forms of medication on 10-point Likert scales and preferences for highest acceptable frequency.

Results: Of 298 patients significantly more found tablets (91%) to be highly acceptable compared to granules (64%), infusions (33%) and subcutaneous injections (34%; p < 0.0001). The acceptable frequency for tablets was considered as daily by 63.5% and several times daily by 32.3%. Participants preferred nurse delivered over self-administered injections (median score 8 vs 5, p < 0.0001) and hospital-based infusions over infusions at home (median score 7 vs 5, p = 0.001). Patients with previous or current anti-TNF exposure were more accepting of self-administered injections (50.5% vs 23.3% anti-TNF naive; p < 0.001), more accepting of home based infusions (43.7% vs 28.0%; p = 0.001) and more accepting of hospital-based infusions (57.2% vs 37.8%; p = 0.02).

Conclusion: Most patients with IBD prefer tablets. Those patients who already experienced biological agents, had a high level of acceptance for subcutaneous and intravenous forms of medication.

摘要

目标：随着炎症性肠病 (IBD) 治疗选择的增加，应考虑患者的偏好以限制不依从性。我们探讨了患者对给药途径、形式和频率的偏好，以及影响这些选择的因素。

方法：患者在 10 点李克特量表上评定不同形式药物的可接受性和对最高可接受频率的偏好。

结果：与颗粒剂 (64%)、输液剂 (33%) 和皮下注射剂 (34%; p < 0.0001) 相比，在 298 名患者中，片剂 (91%) 的接受度明显更高。片剂的可接受频率被认为是每天 63.5% 和每天几次 32.3%。参与者更喜欢护士分娩而不是自我注射（中位得分 8 vs 5，p < 0.0001）和医院输液而不是在家输液（中位得分 7 vs 5，p = 0.001）。以前或当前接触​​过抗 TNF 的患者更能接受自我注射（50.5% 对 23.3% 抗 TNF 初治；p < 0.001），更接受家庭输注（43.7% 对 28.0%；p = 0.001）并且更多地接受基于医院的输液（57.2% vs 37.8%；p = 0.02）。

结论：大多数 IBD 患者更喜欢片剂。那些已经体验过生物制剂的患者对皮下和静脉内药物的接受程度很高。