This study aimed to assess the sex differences in the feeding behaviour of non-obese diabetic severe combined immunodeficient (NOD SCID) mice in a pharmacological model of type 1 diabetes mellitus (T1Dm). In our study, we chose NOD SCID mice of both sexes and assessed their feeding behaviour, body weight, body fat and water content under identical experimental conditions and diets. After 1 month of diabetes mellitus in mice in the experimental group, males and females did not show any increase in body weight, and they weighed significantly less than the control group. However, compared with the control group, in females with a background of T1Dm, there was a significant decrease in body fat. The amount of water consumed in the experimental groups was higher than that in the control groups. The amount of food consumed by males increased when they increased their water consumption, whereas food consumption in females decreased significantly with an increase in water consumption. Thus, we discovered sex differences in the feeding behaviour, body weight and body fat and water content in the pharmacological model of T1Dm after 1 month in NOD SCID mice.

中文翻译：

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1型糖尿病药理模型中NOD SCID小鼠的性别喂养行为差异


本研究旨在评估 1 型糖尿病 (T1Dm) 药理学模型中非肥胖糖尿病严重联合免疫缺陷 (NOD SCID) 小鼠进食行为的性别差异。在我们的研究中，我们选择了两种性别的 NOD SCID 小鼠，并在相同的实验条件和饮食下评估了它们的摄食行为、体重、体脂肪和水含量。实验组小鼠患糖尿病1个月后，雄性和雌性均未出现体重增加，且体重明显低于对照组。然而，与对照组相比，具有T1Dm背景的女性的体脂明显下降。实验组的饮水量高于对照组。男性的食物消耗量随着饮水量的增加而增加，而女性的食物消耗量则随着饮水量的增加而显着减少。因此，我们发现 NOD SCID 小鼠 T1Dm 药理模型 1 个月后在摄食行为、体重、体脂和水含量方面存在性别差异。