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Reaching Deeper: Absolute In Vivo Thermal Reading of Liver by Combining Superbright Ag2S Nanothermometers and In Silico Simulations
Advanced Science ( IF 14.3 ) Pub Date : 2021-03-03 , DOI: 10.1002/advs.202003838
José Lifante 1, 2 , Yingli Shen 2, 3 , Irene Zabala Gutierrez 4 , Irene Rubia-Rodríguez 5 , Daniel Ortega 5, 6, 7 , Nuria Fernandez 1, 2 , Sonia Melle 8 , Miriam Granado 1, 2 , Jorge Rubio-Retama 4 , Daniel Jaque 2, 3 , Erving Ximendes 2, 3
Affiliation  

Luminescent nano‐thermometry is a fast‐developing technique with great potential for in vivo sensing, diagnosis, and therapy. Unfortunately, it presents serious limitations. The luminescence generated by nanothermometers, from which thermal readout is obtained, is strongly distorted by the attenuation induced by tissues. Such distortions lead to low signal levels and entangle absolute and reliable thermal monitoring of internal organs. Overcoming both limitations requires the use of high‐brightness luminescent nanothermometers and adopting more complex approaches for temperature estimation. In this work, it is demonstrated how superbright Ag2S nanothermometers can provide in vivo, reliable, and absolute thermal reading of the liver during laser‐induced hyperthermia. For that, a new procedure is designed in which thermal readout is obtained from the combination of in vivo transient thermometry measurements and in silico simulations. The synergy between in vivo and in silico measurements has made it possible to assess relevant numbers such as the efficiency of hyperthermia processes, the total heat energy deposited in the liver, and the relative contribution of Ag2S nanoparticles to liver heating. This work provides a new way for absolute thermal sensing of internal organs with potential application not only to hyperthermia processes but also to advanced diagnosis and therapy.

中文翻译:


更深入:通过结合超亮 Ag2S 纳米温度计和计算机模拟来读取肝脏的绝对体内热读数



发光纳米测温技术是一种快速发展的技术,在体内传感、诊断和治疗方面具有巨大的潜力。不幸的是,它存在严重的局限性。纳米温度计产生的发光(从中获得热读数)由于组织引起的衰减而严重扭曲。这种失真会导致信号水平较低,并影响对内脏器官的绝对可靠的热监测。克服这两个限制需要使用高亮度发光纳米温度计并采用更复杂的温度估计方法。在这项工作中,展示了超亮 Ag 2 S 纳米温度计如何在激光诱导热疗过程中提供体内​​、可靠和绝对的肝脏热读数。为此,设计了一种新程序,通过结合体内瞬态测温测量和计算机模拟来获得热读数。体内和计算机测量之间的协同作用使得评估相关数据成为可能,例如热疗过程的效率、肝脏中沉积的总热能以及Ag 2 S纳米颗粒对肝脏加热的相对贡献。这项工作为内脏器官的绝对热传感提供了一种新方法,不仅可以应用于热疗过程,还可以应用于高级诊断和治疗。
更新日期:2021-05-05
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