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Uncloaking Breast Tumor Neoantigens with Radiation
Trends in Immunology ( IF 13.1 ) Pub Date : 2021-03-03 , DOI: 10.1016/j.it.2021.02.009
Jenna H Newman 1 , Nina Bhardwaj 1
Affiliation  

Currently, immunotherapy is not effective for all cancer patients, partly due to an inability to mount sufficient tumor-specific T cell responses. Here, we highlight a recent study by Lhuillier et al. demonstrating that radiation potentiates neoantigen expression, eliciting CD4+ and CD8+ T cell responses and tumor growth control in mice.



中文翻译:

用放射线揭示乳腺肿瘤新抗原

目前,免疫疗法并非对所有癌症患者都有效,部分原因是无法产生足够的肿瘤特异性 T 细胞反应。在这里,我们重点介绍 Lhuillier等人最近的一项研究。证明辐射增强了新抗原的表达,在小鼠中引发了 CD4 +和 CD8 + T 细胞反应和肿瘤生长控制。

更新日期:2021-03-25
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