Venlafaxine, a representative antidepressant, has been detected frequently in aquatic environments. The treatment of venlafaxine by free chlorine (NaOCl) and chlorine dioxide (ClO₂) was investigated in this study. The effects of operational variables and the water matrix on venlafaxine degradation were evaluated. The transformation pathways of venlafaxine were also studied. The results indicated that venlafaxine was removed efficiently during disinfection processes, especially when reacted with ClO₂. A higher dosage of disinfectant and mildly alkaline conditions (pH 9) enhanced the degradation of venlafaxine. The reactions were impacted when the tests were conducted in real water matrices, especially in secondary effluent. The presence of chloride and low concentrations of fulvic acid enhanced venlafaxine decomposition. The presence of Br⁻ also accelerated the reaction between venlafaxine and NaOCl. However, NO₂⁻ inhibited venlafaxine removal in both disinfection processes. Six intermediates were identified during venlafaxine degradation by ultrahigh-performance liquid chromatography with quadrupole-time-of-flight mass spectrometry, and the main reactions included dehydration and demethylation.

代表性的抗抑郁药文拉法辛在水生环境中经常被检测到。本研究研究了用游离氯（NaOCl）和二氧化氯（ClO ₂）处理文拉法辛。评估了操作变量和水基质对文拉法辛降解的影响。还研究了文拉法辛的转化途径。结果表明，文拉法辛在消毒过程中被有效去除，尤其是当与ClO ₂反应时。更高剂量的消毒剂和弱碱性条件（pH 9）会增强文拉法辛的降解。在真实的水基质中，特别是在二次废水中进行测试时，反应会受到影响。氯化物和低浓度的富里酸的存在增强了文拉法辛的分解。BR的存在^-也加速文拉法辛和次氯酸钠之间的反应。然而，NO ₂ ^-抑制文拉法辛去除在两个消毒工艺。用四极杆飞行时间质谱通过超高效液相色谱法鉴定了文拉法辛降解期间的六个中间体，主要反应包括脱水和脱甲基。