While converging evidence suggests linguistic roles of white matter tracts, detailed associations between white matter alterations of dual pathways and language abilities remain unknown in aphasic patients. We aimed to verify language functions of dual-pathway tracts from specific domains and investigate the influence of moderators. PubMed, Web of Science, Embase, and CENTRAL were searched for studies published between January 1, 1985 and March 17, 2019. A meta-analysis of 46 studies including 1353 aphasic patients was performed by pooling correlation coefficients between linguistic domains and diffusion metrics of dual-pathway tracts. Among these tracts, the fractional anisotropy (FA) value of the left inferior fronto-occipital fasciculus predominated across most linguistic aspects, showing the strongest correlations with global severity, comprehension, naming and reading ability. The left uncinate fasciculus and inferior longitudinal fasciculus also showed significant FA − comprehension correlations. For syntactic processing, FA values of the left superior longitudinal fasciculus and arcuate fasciculus showed significant positive correlations. Meta-regression revealed no influence of etiology on FA − language correlations, while sex had a moderating effect on the FA − comprehension correlation of the arcuate fasciculus, and age influenced the FA − naming correlation in the superior longitudinal fasciculus. In conclusion, multifunctional characteristics of tracts were revealed in aphasic patients, including broad linguistic associations of the inferior fronto-occipital fasciculus, and repetition and syntactic involvement of the arcuate fasciculus. Language associations of the inferior longitudinal fasciculus and uncinate fasciculus were clarified regarding comprehension subdomains. The insignificant moderating effect of the etiology indicates damage of dual pathways is the common neural mechanism, while sex and age influence the correlation with comprehension and naming ability, respectively, in specific tracts.

虽然越来越多的证据表明白质束的语言作用，但双通路的白质改变与语言能力之间的详细关联在失语症患者中仍然未知。我们旨在验证来自特定领域的双通路区域的语言功能并调查主持人的影响。在 PubMed、Web of Science、Embase 和 CENTRAL 中搜索了 1985 年 1 月 1 日至 2019 年 3 月 17 日期间发表的研究。通过汇集语言域和扩散指标之间的相关系数，对包括 1353 名失语症患者在内的 46 项研究进行了荟萃分析。双通路区。在这些区域中，左下额枕叶束的分数各向异性 (FA) 值在大多数语言方面占主导地位，显示出与整体严重程度的最强相关性，理解、命名和阅读能力。左钩状束和下纵束也显示出显着的 FA - 理解相关性。对于句法处理，左上纵束和弓状束的 FA 值显示出显着的正相关。元回归显示病因对 FA - 语言相关性没有影响，而性别对 FA - 弓状束的理解相关性有调节作用，年龄影响 FA - 上纵束中的命名相关性。总之，在失语症患者中揭示了束的多功能特征，包括下额枕叶束的广泛语言关联，以及弓状束的重复和句法参与。下纵束和钩状束的语言关联在理解子域方面得到了澄清。病因的调节作用不显着表明双通路损伤是常见的神经机制，而性别和年龄分别影响特定区域的理解和命名能力的相关性。