Purpose To determine if losing work during the COVID-19 pandemic is associated with mental and physical health status. To determine if social interactions and financial resources moderate the relationship between work loss and health. Methods Participants were Australians aged 18 + years that were employed in paid work prior to the COVID-19 pandemic who responded to an online or telephone survey from 27^th March to 12^th June 2020 as part of a prospective longitudinal cohort study. Outcome measures include Kessler-6 score > 18 indicating high psychological distress, and Short Form 12 (SF-12) mental health or physical health component score < = 45 indicating poor mental or physical health. Results The cohort consisted of 2,603 respondents, including groups who had lost their job (N = 541), were not working but remained employed (N = 613), were working less (N = 660), and whose work was unaffected (N = 789). Three groups experiencing work loss had greater odds of high psychological distress (AOR = 2.22–3.66), poor mental (AOR = 1.78–2.27) and physical health (AOR = 2.10–2.12) than the unaffected work group. Poor mental health was more common than poor physical health. The odds of high psychological distress (AOR = 5.43–8.36), poor mental (AOR = 1.92–4.53) and physical health (AOR = 1.93–3.90) were increased in those reporting fewer social interactions or less financial resources. Conclusion Losing work during the COVID-19 pandemic is associated with mental and physical health problems, and this relationship is moderated by social interactions and financial resources. Responses that increase financial security and enhance social connections may alleviate the health impacts of work loss. Registration Australian New Zealand Clinical Trials Registry: ACTRN12620000857909.

目的确定在 COVID-19 大流行期间失业是否与身心健康状况有关。确定社交互动和财务资源是否会调节失业与健康之间的关系。方法参与者是在^COVID -19 大流行之前从事有偿工作的 18 岁以上的澳大利亚人，他们在 2020 年 3 月 27^日至 6 月 12日期间对作为前瞻性纵向队列研究的一部分的在线或电话调查做出了回应。结果测量包括 Kessler-6 评分 > 18 表示高度心理困扰，以及 Short Form 12 (SF-12) 心理健康或身体健康部分评分 < = 45 表示心理或身体健康不佳。结果该队列由 2,603 名受访者组成，包括失业（N = 541）、没有工作但仍在工作（N = 613）、工作较少（N = 660）和工作不受影响（N = 789）的群体）。与未受影响的工作组相比，经历失业的三组有更高的心理困扰（AOR = 2.22-3.66）、精神不佳（AOR = 1.78-2.27）和身体健康（AOR = 2.10-2.12）的几率。心理健康状况不佳比身体健康状况不佳更常见。在那些报告社交互动较少或财务资源较少的人中，高心理困扰（AOR = 5.43-8.36）、精神不佳（AOR = 1.92-4.53）和身体健康（AOR = 1.93-3.90）的几率增加。结论在 COVID-19 大流行期间失业与身心健康问题有关，而这种关系受到社会互动和财务资源的影响。增加财务保障和加强社会联系的应对措施可能会减轻失业对健康的影响。注册澳大利亚新西兰临床试验注册：ACTRN12620000857909。