Objective This study aimed to quantify the incidence rates of common mental and physical health conditions in mothers of children with a life-limiting condition. Methods Comparative national longitudinal cohort study using linked primary and secondary care data from the Clinical Practice Research Datalink in England. Maternal–child dyads were identified in these data. Maternal physical and mental health outcomes were identified in the primary and secondary care datasets using previously developed diagnostic coding frameworks. Incidence rates of the outcomes were modelled using Poisson regression, adjusting for deprivation, ethnicity and age and accounting for time at risk. Results A total of 35 683 mothers; 8950 had a child with a life-limiting condition, 8868 had a child with a chronic condition and 17 865 had a child with no long-term condition. The adjusted incidence rates of all of the physical and mental health conditions were significantly higher in the mothers of children with a life-limiting condition when compared with those mothers with a child with no long-term condition (eg, depression: incidence rate ratio (IRR) 1.21, 95% CI 1.13 to 1.30; cardiovascular disease: IRR 1.73, 95% CI 1.27 to 2.36; death in mothers: IRR 1.59, 95% CI 1.16 to 2.18). Conclusion This study clearly demonstrates the higher incidence rates of common and serious physical and mental health problems and death in mothers of children with a life-limiting condition. Further research is required to understand how best to support these mothers, but healthcare providers should consider how they can target this population to provide preventative and treatment services. Data may be obtained from a third party and are not publicly available. the clinical codes used for this study are provided as supplementary material. The patient level data cannot be shared but can be accessed via the Clinical Practice Research Datalink.

中文翻译：

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患有生命限制性疾病的儿童的母亲的健康：一项比较队列研究


目的 本研究旨在量化患有生命受限的儿童的母亲常见心理和身体健康状况的发生率。方法 使用来自英格兰临床实践研究数据链的初级和二级护理数据进行比较全国纵向队列研究。这些数据中确定了母婴二元关系。使用先前开发的诊断编码框架在初级和二级护理数据集中确定了孕产妇的身心健康结果。使用泊松回归对结果的发生率进行建模，调整剥夺、种族和年龄并考虑风险时间。结果 共有 35 683 名母亲； 8950 名儿童患有危及生命的疾病，8868 名儿童患有慢性病，17 865 名儿童没有长期疾病。与孩子没有长期疾病的母亲相比，患有生命限制疾病的母亲的所有身心健康状况的调整后发病率均显着更高（例如，抑郁症：发病率比（ IRR) 1.21，95% CI 1.13 至 1.30；心血管疾病：IRR 1.73，95% CI 1.27 至 2.36；母亲死亡：IRR 1.59，95% CI 1.16 至 2.18。结论 这项研究清楚地表明，患有生命限制性疾病的儿童的母亲常见和严重的身心健康问题和死亡的发生率较高。需要进一步的研究来了解如何最好地支持这些母亲，但医疗保健提供者应该考虑如何针对这一人群提供预防和治疗服务。数据可能从第三方获得，并且不公开。 用于本研究的临床代码作为补充材料提供。患者级别数据无法共享，但可以通过临床实践研究数据链接访问。