ABSTRACT

Background:There is a pressing need for assessment approaches that can be deployed remotely to measure cognitive outcomes in clinical trials and longitudinal aging cohorts. We evaluated the utility of a mobile phone-based intensive measurement study for this purpose. Method:A small cohort of healthy older adults (N = 17, mean age = 73) completed five assessment “bursts” over 12 months, with each measurement burst involving two assessments daily for five consecutive days. Each assessment included brief tests of visual short-term memory and information processing speed, as well as surveys measuring state factors that can affect cognition. Results:At study endpoint we had 94% retention, 97% compliance, and high participant satisfaction. Mobile cognitive test scores demonstrated good reliability, moderate correlations with in-person baseline neuropsychological testing, and significant associations with participant age and education level. Conclusions: Mobile phone-based intensive measurement designs represent a promising assessment approach for measuring cognition longitudinally in older adults.

摘要

背景：迫切需要可以远程部署的评估方法，以测量临床试验和纵向老龄化队列中的认知结果。为此，我们评估了基于手机的密集测量研究的效用。方法：一小群健康的老年人（N = 17，平均年龄 = 73）在 12 个月内完成了五次评估“爆发”，每次测量爆发涉及每天两次评估，连续五天。每项评估都包括对视觉短期记忆和信息处理速度的简短测试，以及测量可能影响认知的状态因素的调查。结果：在研究终点，我们有 94% 的保留率、97% 的依从性和很高的参与者满意度。移动认知测试分数表现出良好的可靠性，与面对面的基线神经心理学测试具有中等相关性，并且与参与者年龄和教育水平显着相关。结论：基于手机的密集测量设计代表了一种有前途的评估方法，用于纵向测量老年人的认知。