Environmental factors, such as chemical exposures, are likely to play a crucial role in the development of several human chronic diseases. However, how the specific exposures contribute to the onset and progress of various diseases is still poorly understood. In part, this is because comprehensive characterization of the chemical exposome is a highly challenging task, both due to its complex dynamic nature as well as due to the analytical challenges. Herein, the analytical challenges in the field of exposome research are reviewed, with specific emphasis on the sampling, sample preparation, and analysis, as well as challenges in the compound identification. The primary focus is on the human chemical exposome, that is, exposures to mixtures of environmental chemicals and its impact on human metabolome. In order to highlight the recent progress in the exposome research in relation to human health and disease, selected examples of human exposome studies are presented.

中文翻译：

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人体暴露组分析中的分析挑战，重点是环境分析与代谢组学相结合

环境因素，如化学品暴露，可能在几种人类慢性疾病的发展中发挥关键作用。然而，具体暴露如何促进各种疾病的发生和进展仍知之甚少。在某种程度上，这是因为化学暴露体的综合表征是一项极具挑战性的任务，因为其复杂的动态性质以及分析挑战。在此，回顾了暴露组研究领域的分析挑战，特别强调了采样、样品制备和分析，以及化合物鉴定方面的挑战。主要关注人类化学暴露体，即暴露于环境化学物质的混合物及其对人类代谢组的影响。