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Pathological and Immunohistochemical Characterization of Thyroid Neoplasms in Cats
Journal of Comparative Pathology ( IF 0.8 ) Pub Date : 2021-03-02 , DOI: 10.1016/j.jcpa.2021.01.013
Fernando F Argenta 1 , Lauren S de Mello 1 , Mônica Slaviero 1 , Fernanda G Cony 1 , Marcele B Bandinelli 1 , Saulo P Pavarini 1 , David Driemeier 1 , Luciana Sonne 1
Affiliation  

There are few pathological and immunohistochemical descriptions of thyroid neoplasms in cats. We investigated neoplasms of the thyroid in 31 cats (average age 15.6 years) in Southern Brazil. Most (96.8%) of these cases were classified as follicular adenomas and were predominantly unilateral and multinodular. Histologically, macrofollicular adenomas were the most common type observed. Carcinomas represented 3.2% of the investigated tumours. By immunohistochemical labelling, thyroglobulin was expressed more commonly than paired box gene 8 or thyroid transcription factor 1 in the follicular adenomas. One carcinoma was immunopositive for thyroglobulin, pancytokeratin, chromogranin A and synaptophysin, suggestive of a calcitonin-negative neuroendocrine carcinoma.



中文翻译:

猫甲状腺肿瘤的病理学和免疫组织化学表征

关于猫甲状腺肿瘤的病理学和免疫组织化学描述很少。我们调查了巴西南部 31 只猫(平均年龄 15.6 岁)的甲状腺肿瘤。这些病例中的大多数 (96.8%) 被归类为滤泡性腺瘤,主要是单侧和多结节。组织学上,大滤泡腺瘤是最常见的类型。癌占所研究肿瘤的 3.2%。通过免疫组织化学标记,甲状腺球蛋白在滤泡腺瘤中的表达比配对盒基因 8 或甲状腺转录因子 1 更常见。一种癌对甲状腺球蛋白、全细胞角蛋白、嗜铬粒蛋白 A 和突触素呈免疫阳性,提示降钙素阴性神经内分泌癌。

更新日期:2021-03-02
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