Polypropylene (PP) scaffolds are the most commonly used biomedical scaffolds despite their disadvantages, which include problems with adhesion, infection, and inflammatory responses. Here, we report on the successful development of a facile one-step method to fabricate a series of novel triclosan polydopamine polypropylene (TPP) composite scaffolds and thereby effectively improve the biocompatibility and long-term antibacterial properties of PP scaffolds. The antibacterial triclosan can effectively interact with dopamine during biocompatible polydopamine formation on the PP scaffold by one-step green fabrication. Thanks to the sustained release of triclosan from the biocompatible polydopamine coating, a 5 mm × 5 mm sample of TPP-coated scaffold made with a triclosan concentration of 8 mg·mL⁻¹ (referred to herein as TPP-8) exhibited a continuous antibacterial effect against both Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) for more than 15 d, at maximum antibacterial volumes of 2 and 5 mL, respectively. Our study establishes a new direction for facile long-term antibacterial studies for medical applications.

聚丙烯（PP）支架尽管有缺点（包括粘附，感染和炎症反应的问题），却是最常用的生物医学支架。在这里，我们报告成功开发一种简便的一步法来制造一系列新型三氯生聚多巴胺聚丙烯（TPP）复合支架，从而有效提高PP支架的生物相容性和长期抗菌性能。通过一步绿色制造，抗菌三氯生可以在PP支架上的生物相容性聚多巴胺形成过程中有效地与多巴胺相互作用。由于三氯生从生物相容性聚多巴胺涂层中的持续释放，制成了5 mm×5 mm的TPP涂层支架样品，其三氯生浓度为8 mg·mL ^-1（本文中称为TPP-8）对大肠杆菌（E. coli）和金黄色葡萄球菌（S. aureus）的抗菌作用持续超过15 d，最大抗菌量分别为2 mL和5 mL。我们的研究为医学应用的简便长期抗菌研究建立了新的方向。