Palinopsia in migraine has been reported recently, which may be due to the dysexcitability of visual cortical neurons. In this cross-sectional study, we report the correlation of neuronal dysexcitability with palinopsia using pattern shift visual evoked potential (PSVEP) in 91 migraineurs and 25 healthy controls. The presence of palinopsia was evaluated using a novel objective method, and revealed more frequent palinopsia in the migraineurs compared to the controls (53 of 91 [58.2%] vs 3 of 25 [12%]; P < .001). Five consecutive blocks of PSVEP were recorded for the evaluation of sensitization and impaired habituation. Amplitudes of N75 and P100 in block 1 were considered for sensitization. Impaired habituation of N75 and P100 was considered if any amplitudes in blocks 2 to 5 were higher than block 1. Impaired habituation was more frequent in migraineurs compared with the controls, and was more marked in wave N75 (81.3% vs 32%; P < .001) than wave P100 (63.7% vs 44%; P = .12). Impaired habituations of wave N75 (81.7% vs 58.9%; P = .008) and wave P100 (71.7% vs 46.4%; P = .008) were more frequent in those with palinopsia compared with those without. There was a lack of suppression of P100 amplitude in block 3 in the palinopsia group compared to the controls. The duration of palinopsia correlated with the extent of impaired habituation of N75. It can be concluded that the impaired habituation of PSVEP waveforms is a biomarker of palinopsia in migraine.

最近报道了偏头痛中的palinopsia，这可能是由于视觉皮层神经元的兴奋性障碍。在这项横断面研究中，我们在 91 名偏头痛患者和 25 名健康对照者中使用模式移位视觉诱发电位 (PSVEP) 报告了神经元兴奋性与错觉的相关性。使用一种新的客观方法评估了pallinopsia的存在，并显示与对照组相比偏头痛患者更频繁的palinopsia（91名中的53名[58.2%] vs 25名中的3名[12%]；P < .001)。记录了五个连续的 PSVEP 块以评估敏感性和习惯受损。块 1 中 N75 和 P100 的幅度被认为是致敏的。如果第 2 到第 5 组中的任何振幅高于第 1 组，则认为 N75 和 P100 的习惯受损。与对照组相比，偏头痛患者的习惯受损更常见，并且在 N75 波中更明显（81.3% vs 32%；P  < .001) 比波 P100 (63.7% vs 44%; P  = .12)。波 N75（81.7% 对 58.9%；P  = .008）和波 P100（71.7% 对 46.4%；P ）的习惯受损 = .008) 与没有错觉的人相比，在有错视症的人中更常见。与对照组相比，palinopsia 组中第 3 组的 P100 振幅缺乏抑制。palinopsia 的持续时间与 N75 的习惯受损程度相关。可以得出结论，PSVEP 波形的习惯性受损是偏头痛中错视的生物标志物。