Recent Advances on Biological Synthesis of Lycopene by Using Industrial Yeast,Industrial & Engineering Chemistry Research

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Recent Advances on Biological Synthesis of Lycopene by Using Industrial Yeast
Industrial & Engineering Chemistry Research ( IF 3.8 ) Pub Date : 2021-02-28 , DOI: 10.1021/acs.iecr.0c05228
Yiwen Jing ₁ , Feng Guo ₁ , Shangjie Zhang ₁ , Weiliang Dong _{1,

2} , Jie Zhou _{1,

2} , Fengxue Xin _{1,

2} , Wenming Zhang _{1,

2} , Min Jiang _{1,

2}

Affiliation

Lycopene has been widely applied in the food and medical fields due to having antioxidant, anticancer, and anti-inflammatory properties. Traditional lycopene production processes including natural extraction and chemical synthesis cannot meet the growing market demand and the pursuit for natural products of consumers. Microbial synthesis of lycopene has offered a promising alternative owing to its unique advantages. Industrial yeasts can produce lycopene by introducing heterologous synthetic pathways, which have become a reliable process to replace plants for lycopene production. In order to increase the lycopene production in industrial yeast, some strategies such as increasing the supply of precursors, looking for the optimal combination of lycopene synthesis genes, modularizing the enzymes in the metabolic pathway, increasing the content of cofactors, reducing product toxicity to cells, and optimizing fermentation methods make industrial yeast an effective strain for producing lycopene. This review mainly summarizes the research progress of lycopene produced by several industrial yeasts, analyzes the factors affecting the lycopene synthesis in the metabolic pathways, and summarizes and prospects the methods and strategies used to achieve high yields of lycopene in yeast to help with future research.

中文翻译：

工业酵母生物合成番茄红素的最新研究进展

番茄红素具有抗氧化，抗癌和抗炎的特性，已被广泛应用于食品和医疗领域。传统的番茄红素生产工艺（包括天然提取和化学合成）无法满足不断增长的市场需求和消费者对天然产物的追求。番茄红素的微生物合成由于其独特的优势而提供了有希望的替代方法。工业酵母可以通过引入异源合成途径来生产番茄红素，这已经成为替代植物生产番茄红素的可靠方法。为了增加工业酵母中番茄红素的产量，一些策略，例如增加前体的供应，寻找番茄红素合成基因的最佳组合，模块化代谢途径中的酶，增加辅助因子的含量，降低产品对细胞的毒性以及优化发酵方法，使工业酵母成为生产番茄红素的有效菌株。本文综述了几种工业酵母生产的番茄红素的研究进展，分析了代谢途径中影响番茄红素合成的因素，并总结和展望了实现酵母中番茄红素高产的方法和策略，以帮助将来的研究。

更新日期：2021-03-10

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