Serum proteins are involved in the regulation of inflammation, and therefore, serum protein profiling provides important insights in diverse inflammatory reactions. Accordingly, concentrations of single APPs, such as the C-reactive protein (CRP), serum amyloid A (SAA), and haptoglobin (Hp), have been described as indicators of inflammatory response in canine pyometra. However, there is little information regarding the overall serum protein profile obtained by SPE in canine pyometra. The present study was thus aimed to identify changes in the serum protein profile to monitor inflammation in dogs with pyometra using serum protein electrophoresis (SPE), in addition to the analysis of the concentration of single acute phase proteins (APPs). By SPE analysis, decreased levels of albumin and elevated levels of α2-globulin and β-globulin were noted in dogs with pyometra. In addition, the concentration of APPs, including the C-reactive protein (CRP), serum amyloid A (SAA), and haptoglobin (Hp), were also elevated in dogs with pyometra. The present study provides fundamental data for inflammatory indicators of canine pyometra.

血清蛋白参与炎症的调节，因此，血清蛋白谱分析在各种炎症反应中提供了重要的见识。因此，单一APP的浓度，例如C反应蛋白（CRP），血清淀粉样蛋白A（SAA）和触珠蛋白（Hp），已被描述为犬脓毒症中炎症反应的指标。但是，关于犬脓毒症中SPE获得的总体血清蛋白谱的信息很少。因此，本研究旨在鉴定血清蛋白谱的变化，以利用血清蛋白电泳（SPE）来监测脓毒症犬的炎症，并分析单个急性期蛋白（APP）的浓度。通过SPE分析，在脓液犬中发现白蛋白水平降低，α2-球蛋白和β-球蛋白水平升高。此外，患有脓疱病的狗中包括C反应蛋白（CRP），血清淀粉样蛋白A（SAA）和触珠蛋白（Hp）在内的APP浓度也升高。本研究为犬脓毒症的炎症指标提供了基础数据。