Abstract

Purpose

This study aimed to explore the accuracy of different imaging methods for lesion volume estimation pre- and post-microwave ablation (MWA) as compared with that of pathological examination.

Methods

We used the VX2 cell line to establish the VX2 lung tumor model in rabbits, followed by MWA of the tumor. The imaging features of the VX2 tumors were documented. The volume of the tumors and the ablated lesions were measured and compared across imaging methods, using the pathological examination as reference.

Results

Tumors were successfully developed in 11 rabbits (age, 13.91 ± 1.38 weeks; weight, 2.15 ± 0.56 kg). The mean volume of the tumors was 2.05 ± 1.88 cm³. CT showed the strongest correlation with the pathologic examination results (r = 0.998, p<.001). MWA created three-layered structures that were delineated on MRI. The mean volume of the post-ablation lesion was 10.39 ± 8.93 cm³, and the measurement of the post-ablation volume on 3D-VIBE-T1WI showed the strongest correlation with the pathologic examination results (r = 0.991, p<.001).

Conclusion

Both CT and MRI are capable of depicting lung tumors. In terms of post-ablation evaluation, MR images could provide more versatile information. The 3D-VIBE-T1WI sequence provides more precise lesion volume evaluation after ablation compared with other methods.

中文翻译：

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计算机断层扫描和磁共振图像对兔肺VX2肿瘤微波消融灶的影像学特征及其与病理学检查的关系

摘要

目的

本研究旨在探讨与病理学检查相比，在微波消融前后评估病变体积的不同成像方法的准确性。

方法

我们使用VX2细胞系在兔中建立VX2肺部肿瘤模型，然后建立肿瘤的MWA。记录了VX2肿瘤的影像学特征。使用病理学检查作为参考，通过成像方法测量并比较了肿瘤和消融灶的体积。

结果

在11只兔子中成功地发展了肿瘤（年龄13.91±1.38周；体重2.15±0.56kg）。肿瘤的平均体积为2.05±1.88cm ³。CT显示与病理检查结果之间的相关性最强（r  = 0.998，p <.001）。MWA创建了在MRI上描绘的三层结构。消融后病变的平均体积为10.39±8.93 cm ³，在3D-VIBE-T1WI上测量消融后体积与病理检查结果之间的相关性最强（r  = 0.991，p <.001） 。

结论

CT和MRI均能够描绘出肺部肿瘤。在消融后评估方面，MR图像可提供更多用途的信息。与其他方法相比，消融后的3D-VIBE-T1WI序列可提供更精确的病变体积评估。