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Cell‐Laden Multiple‐Step and Reversible 4D Hydrogel Actuators to Mimic Dynamic Tissue Morphogenesis
Advanced Science ( IF 14.3 ) Pub Date : 2021-03-01 , DOI: 10.1002/advs.202004616
Aixiang Ding 1, 2, 2 , Oju Jeon 1, 2, 2 , Rui Tang 1, 2, 2 , Yu Bin Lee 1, 2, 2 , Sang Jin Lee 1, 2, 2 , Eben Alsberg 1, 2, 2, 3, 4, 4
Affiliation  

Shape‐morphing hydrogels bear promising prospects as soft actuators and for robotics. However, they are mostly restricted to applications in the abiotic domain due to the harsh physicochemical conditions typically necessary to induce shape morphing. Here, multilayer hydrogel actuator systems are developed using biocompatible and photocrosslinkable oxidized, methacrylated alginate and methacrylated gelatin that permit encapsulation and maintenance of living cells within the hydrogel actuators and implement programmed and controlled actuations with multiple shape changes. The hydrogel actuators encapsulating cells enable defined self‐folding and/or user‐regulated, on‐demand‐folding into specific 3D architectures under physiological conditions, with the capability to partially bioemulate complex developmental processes such as branching morphogenesis. The hydrogel actuator systems can be utilized as novel platforms for investigating the effect of programmed multiple‐step and reversible shape morphing on cellular behaviors in 3D extracellular matrix and the role of recapitulating developmental and healing morphogenic processes on promoting new complex tissue formation.

中文翻译:


充满细胞的多步可逆 4D 水凝胶致动器模拟动态组织形态发生



变形水凝胶作为软执行器和机器人具有广阔的前景。然而,由于诱导形状变形通常需要恶劣的物理化学条件,因此它们大多仅限于在非生物领域的应用。在这里,多层水凝胶致动器系统是使用生物相容性和可光交联的氧化、甲基丙烯酸藻酸盐和甲基丙烯酸明胶开发的,允许在水凝胶致动器内封装和维持活细胞,并实现具有多种形状变化的编程和控制致动。封装细胞的水凝胶执​​行器能够在生理条件下实现定义的自折叠和/或用户调节的按需折叠成特定的 3D 结构,并能够部分生物模拟复杂的发育过程,例如分支形态发生。水凝胶执行器系统可用作新平台,用于研究程序化多步和可逆形状变形对 3D 细胞外基质中细胞行为的影响,以及重现发育和愈合形态发生过程在促进新的复杂组织形成中的作用。
更新日期:2021-05-05
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