Follicular helper T cells (T_FH) are essential B cell-help providers in the formation of germinal centers (GCs), affinity maturation of GC B cells, differentiation of high-affinity antibody-producing plasma cells, and production of memory B cells. The transcription factor (TF) B cell lymphoma 6 (Bcl6) is at the center of gene regulation in T_FH biology, including differentiation and function, but how Bcl6 does this, and what additional TFs contribute, remain complex questions. This review focuses on advances in our understanding of Bcl6-mediated gene regulation of T_FH functions, and the modulation of T_FH by other TFs. These advances may have important implications in deciphering how repressor TFs can regulate many immunological cell types. An improved understanding of T_FH biology will likely provide insights into biomedically relevant diseases.

卵泡辅助性T细胞（_TFH）是生发中心（GC）的形成，GC B细胞的亲和力成熟，产生高亲和力的抗体浆细胞的分化以及记忆B细胞的产生中必不可少的B细胞帮助提供者。转录因子（TF）B细胞淋巴瘤6（Bcl6）是T _FH生物学中基因调控的中心，包括分化和功能，但是Bcl6如何做到这一点以及其他TF起作用仍然是复杂的问题。这次审查的重点在我们的牛逼Bcl6转录因子介导的基因调控的理解进步_FH功能，以及T的调制_FH通过其他TF。这些进展可能在解读阻遏物TFs如何调节许多免疫细胞类型方面具有重要意义。更好地了解T _FH生物学可能会提供有关生物医学相关疾病的见识。