当前位置: X-MOL 学术Biomech. Model. Mechanobiol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Experimental tracking and numerical mapping of novel coronavirus micro-droplet deposition through nasal inhalation in the human respiratory system
Biomechanics and Modeling in Mechanobiology ( IF 3.0 ) Pub Date : 2021-03-01 , DOI: 10.1007/s10237-021-01434-8
Hamidreza Mortazavy Beni , Hamed mortazavi , Fatemeh Aghaei , Sanam Kamalipour

It is essential to study the viral droplet’s uptake in the human respiratory system to better control, prevent, and treat diseases. Micro-droplets can easily pass through ordinary respiratory masks. Therefore, the SARS-COV-2 transmit easily in conversation with a regular mask with 'silent spreaders' in the most physiological way of breathing through the nose, indoor and at rest condition. The results showed that the amount of deposited micro-droplets in the olfactory epithelium area is low. Also, due to receptors and long droplet residence time in this region, the possibility of absorption increases in the cribriform plate. This phenomenon eventually could lead to brain lesion damage and, in some cases, leads to stroke. In all inlet flow rates lower than 30 L/min inlet boundary conditions, the average percentage of viral contamination for upper respiratory tract is always less than 50% and more than 50% for the lungs. At 6L/min and 15L/min flow rates, the average percentage of lung contamination increases to more than 87%, which due to the presence of the Coronavirus receptor in the lungs, the involvement of the lungs increases significantly. This study's other achievements include the inverse relationship between droplets deposition efficiency in some parts of the upper airway, which have the most deformation in the tract. Also, the increased deformities per minute applied to the trachea and nasal cavity, which is 1.5 times more than usual, could lead to chest and head bothers.



中文翻译:

在人的呼吸系统中通过鼻吸入新的冠状病毒微滴沉积的实验跟踪和数值作图

研究人体呼吸系统中病毒滴的吸收对更好地控制,预防和治疗疾病至关重要。微滴可以很容易地穿过普通的呼吸面罩。因此,SARS-COV-2与带有“无声散布器”的常规面罩对话时,可以以最生理的方式通过鼻子,室内和休息状态呼吸,从而轻松传播。结果显示,在嗅上皮区域中沉积的微滴的数量低。同样,由于受体和在该区域中的长液滴停留时间,在网状板中吸收的可能性增加。这种现象最终可能导致脑部损伤,并在某些情况下导致中风。在所有入口流量低于30 L / min入口边界条件的情况下,上呼吸道病毒污染的平均百分比始终小于50%,而肺脏则大于50%。在6升/分钟和15升/分钟的流速下,肺部污染的平均百分比增加到87%以上,这归因于肺中冠状病毒受体的存在,肺部的受累程度显着增加。这项研究的其他成就包括在上呼吸道某些部位的液滴沉积效率之间的反比关系,这些部位在管道中变形最大。同样,每分钟施加到气管和鼻腔的畸形增加了,比平时增加了1.5倍,这可能会导致胸部和头部的不适。肺污染的平均百分比增加到超过87%,这归因于肺中冠状病毒受体的存在,肺部的受累程度显着增加。这项研究的其他成就包括在上呼吸道某些部位的液滴沉积效率之间的反比关系,这些部位在管道中变形最大。同样,每分钟施加到气管和鼻腔的畸形增加了,比平时增加了1.5倍,这可能会导致胸部和头部的不适。肺污染的平均百分比增加到超过87%,这归因于肺中冠状病毒受体的存在,肺部的受累程度显着增加。这项研究的其他成就包括在上呼吸道某些部位的液滴沉积效率之间的反比关系,这些部位在管道中变形最大。同样,每分钟施加到气管和鼻腔的畸形增加了,比平时增加了1.5倍,这可能会导致胸部和头部的不适。在管道中变形最大的 同样,每分钟施加到气管和鼻腔的畸形增加了,比平时增加了1.5倍,这可能会导致胸部和头部的不适。在管道中变形最大的 同样,每分钟施加到气管和鼻腔的畸形增加了,比平时增加了1.5倍,这可能会导致胸部和头部的不适。

更新日期:2021-03-01
down
wechat
bug