HACEK (Haemophilus spp., Aggregatibacter spp., Cardiobacterium spp., Eikenella corrodens, and Kingella spp.) group organisms are responsible for 0.8% to 6% of all infective endocarditis cases, with Cardiobacterium spp. being the third most commonly implicated HACEK microorganism. Within this genus is Cardiobacterium valvarum (C. valvarum), a novel organism described in 2004. To date, only 15 cases of C. valvarum infection have been reported in the English-language literature, and have primarily been cases of infective endocarditis in patients with valvular disease. C. valvarum has not been reported to cause infections spreading to the surrounding bone. We present a case of a 57-year-old man with a history of aortic dissection followed by aortic endograft replacement who presented with back pain. He was found to have radiographic evidence of an infected aortic endograft, along with vertebral osteomyelitis, discitis, and epidural phlegmon. Blood cultures identified C. valvarum as the causative organism. The patient was treated with ceftriaxone and surgical intervention was deferred due to the patient’s complex anatomy. His course was complicated by septic cerebral emboli resulting in cerebrovascular accident. This case report highlights C. valvarum, a rare and emerging HACEK group microorganism that warrants consideration in high-risk patients with evidence of subacute infection and disseminated disease. While C. valvarum classically presents as infective endocarditis, extra-cardiac manifestations have also been described. As demonstrated in this case, endograft involvement and osteomyelitis may occur in rare circumstances.

中文翻译：

---

心脏瓣膜病菌引起主动脉移植物感染和骨髓炎的罕见病例

HACEK（嗜血杆菌属、聚合杆菌属、心杆菌属、腐蚀艾肯氏菌和金氏杆菌属）组生物占所有感染性心内膜炎病例的 0.8% 至 6%，其中心杆菌属。是第三个最常见的 HACEK 微生物。在这个属中，心脏杆菌（C. valvarum）是 2004 年描述的一种新生物。 迄今为止，英语文献中仅报道了 15 例 C. valvarum 感染，并且主要是患者感染性心内膜炎的病例伴有瓣膜病。没有报道 C. valvarum 会导致感染扩散到周围的骨骼。我们介绍了一例 57 岁男性，有主动脉夹层病史，随后进行主动脉内移植物置换术，并出现背痛。他被发现有受感染的主动脉内移植物的放射学证据，以及椎骨骨髓炎、椎间盘炎和硬膜外痰。血培养确定 C. valvarum 为致病微生物。患者接受头孢曲松治疗，由于患者解剖结构复杂，手术干预被推迟。他的病程因化脓性脑栓塞而复杂化，导致脑血管意外。本病例报告重点介绍了 C. valvarum，这是一种罕见的新兴 HACEK 群微生物，值得在有亚急性感染和播散性疾病证据的高危患者中考虑。虽然 C. valvarum 典型地表现为感染性心内膜炎，但也描述了心外表现。如本例所示，在极少数情况下可能会发生内移植物受累和骨髓炎。