Background: Evidence is emerging that individuals with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) may suffer from chronic vascular dysfunction as a result of illness-related oxidative stress and vascular inflammation. The study aimed to examine the impact of maximal-intensity aerobic exercise on vascular function 48 and 72 h into recovery. Methods: ME/CFS (n = 11) with gender and age-matched controls (n = 11) were randomly assigned to either a 48 h or 72 h protocol. Each participant had measures of brachial blood pressure, augmentation index (AIx75, standardized to 75 bpm) and carotid-radial pulse wave velocity (crPWV) taken. This was followed by a maximal incremental cycle exercise test. Resting measures were repeated 48 or 72 h later (depending on group allocation). Results: No significant differences were found when ME/CFS were directly compared to controls at baseline. During recovery, the 48 h control group experienced a significant 7.2% reduction in AIx75 from baseline measures (p < 0.05), while the matched ME/CFS experienced no change in AIx75. The 72 h ME/CFS group experienced a non-significant increase of 1.4% from baseline measures. The 48 h and 72 h ME/CFS groups both experienced non-significant improvements in crPWV (0.56 ms⁻¹ and 1.55 ms⁻¹, respectively). Conclusions: The findings suggest that those with ME/CFS may not experience exercise-induced vasodilation due to chronic vascular damage, which may be a contributor to the onset of post-exertional malaise (PEM).

中文翻译：

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运动后不适对肌病性脑脊髓炎/慢性疲劳综合症患者的动脉僵硬度标记值的影响

背景：越来越多的证据表明，患有肌病性脑脊髓炎/慢性疲劳综合症（ME / CFS）的人可能会因与疾病相关的氧化应激和血管炎症而患有慢性血管功能障碍。这项研究旨在检查最大强度的有氧运动对恢复后48和72 h的血管功能的影响。方法： ME / CFS（n = 11），性别和年龄相匹配的对照组（n= 11）被随机分配为48小时或72小时方案。每位参与者均测量了肱动脉血压，增强指数（AIx75，标准化为75 bpm）和颈动脉radi动脉脉搏波速度（crPWV）。随后进行最大增量循环运动测试。48或72小时后重复休息措施（取决于组分配）。结果：将ME / CFS与基线时的对照组直接比较时，没有发现显着差异。在恢复过程中，48小时对照组的AIx75较基线水平显着降低了7.2％（p<0.05），而匹配的ME / CFS的AIx75没有变化。72小时的ME / CFS组较基线指标无显着增加1.4％。48 h和72 h ME / CFS组的crPWV均无明显改善（分别为0.56 ms ^-1和1.55 ms ^-1）。结论：研究结果表明，ME / CFS患者可能由于慢性血管损伤而未经历运动引起的血管舒张，这可能是劳累后不适（PEM）发作的原因。