Polycystic ovary syndrome (PCOS) is a common hormonal disorder that has a huge impact on the human infertility. Increased levels of various circulating inflammatory cytokines have been observed in PCOS patients, which can contribute to the pathogenesis of PCOS. Monocyte chemoattractant protein-1 (MCP-1), a secretory chemokine, is a potent chemotactic factor that recruits monocytes/macrophages to inflammatory foci. Several previous studies comparing the circulating MCP-1 levels between non-PCOS and PCOS patients have yielded contradictory results. Therefore, the aim of this meta-analysis was to investigate whether circulating MCP-1 levels vary between non-PCOS and PCOS patients.

中文翻译：

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循环单核细胞趋化蛋白 1 水平与多囊卵巢综合征的关联：荟萃分析

多囊卵巢综合征（PCOS）是一种常见的激素紊乱，对人类不孕症影响巨大。在 PCOS 患者中观察到各种循环炎性细胞因子水平升高，这可能有助于 PCOS 的发病机制。单核细胞趋化蛋白-1 (MCP-1) 是一种分泌趋化因子，是一种有效的趋化因子，可将单核细胞/巨噬细胞募集到炎性病灶。之前的几项研究比较了非 PCOS 和 PCOS 患者之间的循环 MCP-1 水平，得出了相互矛盾的结果。因此，这项荟萃分析的目的是调查循环 MCP-1 水平是否在非 PCOS 和 PCOS 患者之间存在差异。