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A virucidal face mask based on the reverse-flow reactor concept for thermal inactivation of SARS-CoV-2
AIChE Journal ( IF 3.5 ) Pub Date : 2021-02-28 , DOI: 10.1002/aic.17250
Samuel Faucher 1 , Daniel James Lundberg 1 , Xinyao Anna Liang 2 , Xiaojia Jin 1 , Rosalie Phillips 1 , Dorsa Parviz 1 , Jacopo Buongiorno 2 , Michael S Strano 1
Affiliation  

While facial coverings reduce the spread of SARS-CoV-2 by viral filtration, masks capable of viral inactivation by heating can provide a complementary method to limit transmission. Inspired by reverse-flow chemical reactors, we introduce a new virucidal face mask concept driven by the oscillatory flow of human breath. The governing heat and mass transport equations are solved to evaluate virus and CO2 transport. Given limits imposed by the kinetics of SARS-CoV-2 thermal inactivation, human breath, safety, and comfort, heated masks may inactivate SARS-CoV-2 to medical-grade sterility. We detail one design, with a volume of 300 ml at 90°C that achieves a 3-log reduction in viral load with minimal impedance within the mask mesh, with partition coefficient around 2. This is the first quantitative analysis of virucidal thermal inactivation within a protective face mask, and addresses a pressing need for new approaches for personal protective equipment during a global pandemic.

中文翻译:


基于逆流反应器概念的杀病毒口罩,可热灭活 SARS-CoV-2



虽然面部覆盖物通过病毒过滤减少 SARS-CoV-2 的传播,但能够通过加热灭活病毒的口罩可以提供限制传播的补充方法。受逆流化学反应器的启发,我们引入了一种由人类呼吸的振荡流动驱动的新的杀病毒面罩概念。求解控制热和质量传输方程以评估病毒和CO 2传输。考虑到 SARS-CoV-2 热灭活动力学、人类呼吸、安全性和舒适性的限制,加热口罩可能会将 SARS-CoV-2 灭活至医疗级无菌状态。我们详细介绍了一种设计,在 90°C 下体积为 300 毫升,可实现病毒载量减少 3 个对数级,且面罩网内的阻抗最小,分配系数约为 2。这是对杀病毒热灭活的首次定量分析防护口罩,并解决了全球大流行期间对个人防护设备新方法的迫切需求。
更新日期:2021-02-28
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