The link between the gut microbiome and responsiveness to immune checkpoint inhibitor (ICI) therapy is now well established. New therapeutic opportunities exploiting this relationship are being developed with the goal of augmenting ICI efficacy. In this review, we summarize the foundational research establishing these interactions and discuss the mechanisms and novel therapeutic options associated with this gut microbiome-ICI connection.

中文翻译：

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与肠道微生物群介导的免疫检查点抑制剂反应调节相关的治疗干预和机制

肠道微生物组与免疫检查点抑制剂 (ICI) 治疗的反应之间的联系现已得到充分确立。正在开发利用这种关系的新治疗机会，目的是提高 ICI 的疗效。在这篇综述中，我们总结了建立这些相互作用的基础研究，并讨论了与这种肠道微生物组-ICI 联系相关的机制和新的治疗选择。