The paper focuses on the SiO_x-doped amorphous hydrocarbon (a-C:H:SiO_x) coating on the titanium (Ti-6Al-4V) alloy substrate obtained by plasma-assisted chemical vapor deposition (PACVD) in a mixture of argon gas and polyphenylmethylsiloxane vapor using a bipolar substrate bias. It is shown that the a-C:H:SiO_x coating deposition results in the formation of a negative surface potential important for application of this coating for medical implants. The a-C:H:SiO_x coatings improve the corrosion resistance of Ti alloy to 0.5 M NaCl solution and phosphate-buffered saline. In particular, the corrosion current density of the a-C:H:SiO_x-coated sample in a 0.5 M NaCl solution at 22 °C decreases from 1∙10⁻⁸ to 1.7∙10⁻¹⁰ A/cm², that reduces the corrosion rate from 9∙10⁻⁵ to 15∙10⁻⁷ mm/year. The a-C:H:SiO_x coating facilitates the surface endothelization of an implant located in the thoracic aorta of a mini pig, and reduces the risk of thrombosis and implant failure. This effect can be explained by the ability of the a-C:H:SiO_x coating ability to reduce in vitro a 24-hour secretion of pro-inflammatory interleukins (IL-6, IL-12(p70), IL-15, and IL-17) and cytokines (IFN-g and TNF-a) by blood mononuclear cells (MNCs) and elevates the concentration of anti-inflammatory interleukin IL-1Ra. In vitro analysis shows no cytotoxicity of the a-C:H:SiO_x coating for the human blood MNCs, suggesting a promising PACVD on Ti alloys for cardiovascular implants, including pumps for mechanical heart support systems.

本文重点研究了在氩气和氩气的混合气体中通过等离子体辅助化学气相沉积（PACVD）获得的钛（Ti-6Al-4V）合金基底上的SiO _x掺杂无定形烃（aC：H：SiO _x）涂层。聚苯甲基硅氧烷蒸气使用双极基材偏压。结果表明，aC：H：SiO _x涂层的沉积导致形成负表面电势，这对于将该涂层用于医疗植入物很重要。aC：H：SiO _x涂层提高了Ti合金对0.5 M NaCl溶液和磷酸盐缓冲盐水的耐腐蚀性。特别是，在22°C下0.5M NaCl溶液中aC：H：SiO _x涂层样品的腐蚀电流密度从1∙10降低⁻⁸至1.7∙10 ^-10 A / cm ²，将腐蚀速率从9∙10 ^-5降低至15∙10 ^-7  mm /年。aC：H：SiO _x涂层可促进小型猪胸主动脉中植入物的表面内皮化，并降低血栓形成和植入物失败的风险。可以通过aC：H：SiO _x涂层在体外减少促炎性白介素（IL-6，IL-12（p70），IL-15和IL）24小时分泌的能力来解释这种作用-17）和血液单核细胞（MNC）产生的细胞因子（IFN-g和TNF-a），并提高了抗炎性白介素IL-1Ra的浓度。体外分析表明，aC：H：SiO _x涂层对人体血液MNC没有细胞毒性，这表明在用于心血管植入物（包括用于机械心脏支持系统的泵）的钛合金上有希望的PACVD。