People with psychosis are reported to be one of the most stigmatised minority groups in society. Mental health stigma can have a detrimental impact on quality of life (QoL), which is a meaningful outcome for service users experiencing psychosis and using mental health services. This paper provides the first systematic literature review, meta-analysis and quality appraisal of studies examining the association between stigma and subjective QoL in non-affective psychosis. An electronic database search identified 45 articles for inclusion. A random-effects meta-analysis of 37 independent samples (n = 5795) found a statistically significant association between higher stigma and lower subjective QoL of medium strength (r = −0.40, 95% CI: −0.45, −0.35). Separate meta-analyses demonstrated medium-to-large negative pooled effects for self-stigma (k = 25, r = −0.44, 95% CI:-0.49, −0.38), perceived stigma (k = 10, r = −0.32, 95% CI:-0.42, −0.21) and experienced stigma (k = 6, r = −0.30, 95% CI:-0.35, −0.24). A narrative summary of 12 studies suggested psychological mechanisms relating to self-concept and social networks may play an important mediating role in the association between stigma and QoL in psychosis. Psychological interventions should target improvements in these psychological processes to reduce the negative impact of stigma on QoL in psychosis. Further longitudinal research is needed to test theoretical models of causal pathways and explanatory mechanisms.

据报道，精神病患者是社会上最受歧视的少数群体之一。心理健康污名会对生活质量 (QoL) 产生不利影响，这对于经历精神病和使用心理健康服务的服务使用者来说是一个有意义的结果。本文提供了第一个系统的文献综述、荟萃分析和质量评估，这些研究检查了非情感性精神病中耻辱感与主观 QoL 之间的关联。电子数据库搜索确定了 45 篇文章以供收录。对 37 个独立样本 ( n  = 5795)的随机效应荟萃分析发现，较高的耻辱感与较低的中等强度主观 QoL 之间存在统计学上显着的关联 ( r  = -0.40, 95% CI: -0.45, -0.35)。单独的荟萃分析证明了对自我污名 ( k  =  25 , r  = -0.44, 95% CI:-0.49, -0.38)、感知污名 ( k  =  10, r  =  -0.32, 95% CI:-0.42, -0.21) 和经历过的耻辱 ( k  =  6, r = -0.30, 95% CI:-0.35, -0.24)。12 项研究的叙述性总结表明，与自我概念和社交网络相关的心理机制可能在精神病的耻辱感和 QoL 之间的关联中发挥重要的中介作用。心理干预应针对这些心理过程的改善，以减少耻辱感对精神病患者生活质量的负面影响。需要进一步的纵向研究来测试因果途径和解释机制的理论模型。